Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1831
Title: Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain
Authors: Devanarayana, N.M.
de Silva, D.G.H.
de Silva, H.J.
Issue Date: 2008
Publisher: Wiley-Blackwell
Citation: Journal of Gastroenterology and Hepatology. 2008; 23(11): 1672-77
Abstract: BACKGROUND AND AIMS: Recurrent abdominal pain is common among children and adolescents. The majority of the affected patients have no apparent cause for their symptoms. This study evaluated gastric myoelectrical activity and motility abnormalities in children and adolescents with functional recurrent abdominal pain. METHODS: Forty-two children with functional recurrent abdominal pain [19 (45.2%) males, mean 8 years, SD 3 years, 19 functional abdominal pain, 9 irritable bowel syndrome, 9 functional dyspepsia, 1 abdominal migraine, 1 aerophagia and 3 non-specific abdominal pain according to Rome III criteria] and 20 healthy children [10 (50%) males, mean 9 years, SD 2.7 years] from the same geographical area underwent electrogastrography (EGG), and ultrasonographic assessment of gastric emptying rate and antral motility. RESULTS: Average gastric emptying rate, amplitude of antral contractions and antral motility index were lower in patients (46.5%, 74.3% and 6.5 respectively) compared to controls (66.17%, 89% and 8.3 respectively) (P < 0.001). Gastric emptying rate had a negative correlation with scores obtained for severity of symptoms (r = -0.63, P < 0.0001). Postprandial dominant frequency instability co-efficient (post-DFIC) was higher in patients than in controls (27.83% vs 18.3%, P = 0.0087), and correlated with the symptom score (r = 0.26, P = 0.045). CONCLUSIONS: Gastric emptying and antral motility were significantly impaired in patients, indicating a possible role for gastric motility disturbances in the pathogenesis of childhood functional recurrent abdominal pain. Further studies, including therapeutic trials, are needed to confirm this association and for recommendation of prokinetic drugs in its management.
Description: Indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/1831
ISSN: 0815-9319 (Print)
1440-1746 (Electronic)
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.