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DC Field | Value | Language |
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dc.contributor.author | Siriwardana, R.C. | en_US |
dc.contributor.author | Liyanage, C.A.H. | en_US |
dc.contributor.author | Gunetilleke, B. | en_US |
dc.contributor.author | Niriella, M.A. | en_US |
dc.contributor.author | de Silva, H.J. | en_US |
dc.contributor.author | Dassanayake, A.S. | en_US |
dc.contributor.author | Jayatunga, S.P. | en_US |
dc.date.accessioned | 2017-11-01T07:25:50Z | en_US |
dc.date.available | 2017-11-01T07:25:50Z | en_US |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Gastrointestinal Tumors.2017;4(1-2):20-27 | en_US |
dc.identifier.issn | 2296-3774 (Print) | en_US |
dc.identifier.issn | 2296-3766 (Electronic) | en_US |
dc.identifier.issn | 2296-3774 (Linking) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/17941 | en_US |
dc.description | Indexed in PUBMED, Not in MEDLINE | en_US |
dc.description.abstract | BACKGROUND: Data on diffuse-type hepatocellular carcinoma (HCC) are rare. HCC in Sri Lanka is rising, and the majority is related to nonalcoholic fatty liver disease. This study was planned to compare nodular- and diffuse-type HCC in this cohort. METHODS: CT scans of 227 patients with HCC negative for infective hepatitis were analyzed and grouped as nodular and diffuse from July 2011 to July 2014. Diffuse-type cancer was defined as a tumor without convex/distinct margin, diffusely infiltrating the hepatic parenchyma. There were 45 (20%) cases. The baseline liver functions, etiology, treatment, and the outcome were compared with nodular-type cancers. Stage III diffuse cancers were matched with 2 stage III nodular cancers looking at the T stage and background liver. RESULTS: There was no difference in the age (63 vs. 62 years, p = 0.937) and gender. Diffuse cancers had a low BMI (24 vs. 22, p = 0.009), a higher alpha fetoprotein (AFP) level (p < 0.001), a higher incidence of major vascular invasion (14 vs. 80%, p < 0.001), and a history of significant alcohol consumption (39 vs. 67%, p = 0.001). The baseline liver functions were similar in diffuse and nodular cancers. A large proportion (27 vs.77%, p < 0.001) of diffuse cancers were not candidates for active treatment. Overall survival was poor in the diffuse type(4.7 vs. 25 months, p < 0.001). Diffuse-type stage III cancers had a poor survival compared to matched nodular cancers (2.5 vs. 15.8 months, p = 0.001). CONCLUSION: HCC without a background of infective hepatitis were common in our cohort. These tumors are associated with high AFP levels, major vascular invasion, and a poor prognosis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Karger Medical and Scientific Publishers | en_US |
dc.subject | Carcinoma, Hepatocellular | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular-diagnosis | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular-pathology | en_US |
dc.subject.mesh | Neoplasm Staging | en_US |
dc.subject.mesh | Neoplasm Invasiveness | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.title | Diffuse-Type Hepatoma: A grave prognostic marker | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
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