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DC Field | Value | Language |
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dc.contributor.author | Niriella, M.A. | |
dc.contributor.author | Kodisinghe, S.K. | |
dc.contributor.author | Dinamithra, N.P. | |
dc.contributor.author | Rajapakshe, N. | |
dc.contributor.author | Nanayakkara, S.D. | |
dc.contributor.author | Luke, H.P.D.P. | |
dc.contributor.author | Silva, K.T.M. | |
dc.contributor.author | de Silva, A.P. | |
dc.contributor.author | Navarathne, N.M.M. | |
dc.contributor.author | de Silva, H.J. | |
dc.date.accessioned | 2017-10-20T09:51:08Z | |
dc.date.available | 2017-10-20T09:51:08Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Sri Lanka Medical Association, 130th Anniversary International Medical Congress. 2017;62(Supplement 1):80 | en_US |
dc.identifier.issn | 0009-0895 | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/17848 | |
dc.description | Oral Presentation Abstract (OP 049), 130th Anniversary International Medical Congress, Sri Lanka Medical Association, 13th-16th July 2017 Colombo, Sri Lanka | en_US |
dc.description.abstract | INTRODUCTION & OBJECTIVES: Rural/urban and coastal/inland environmental influences on inflammatory bowel disease (IBD) is poorly studied. We investigated such environmental influences on IBD. METHODS: Patients with histologically proven IBD [ulcerative colitis (UC), Crohn disease (CD)] with a permanent residence and regular follow up, were included. Urban areas (UA) were defined as those administered by Municipal and Urban councils. Coastal areas (CA) were defined as areas with elevation <30 meters above sea level. Patients in different groups were compared with regard to phenotype of IBD [sex, age at diagnosis, Montreal subgroups, severity, extraintestinal manifestation (EIM) at diagnosis, and highest therapy during follow-up]. Fisher’s exact test was used to compare categorical variables. RESULTS: A total of 387 patients were included [UC-251 (64.8%), males-122 (48.6%), median followup (IQR)-22.5 (2-59) months; CD-136 (35.2%), males-65 (47.8%), median follow-up (IQR)- 63.0 (23-115) months; urban/rural distribution: UC-1.7:1, CD-1.5:1; coastal/inland distribution: both UC and CD-0.7:1]. Urban/rural or coastal/inland location did not affect the distribution of type of IBD, gender, age at diagnosis or presence of EIM. UC patients from rural areas had extensive disease (E3) (42.4% vs 24.5%, p=0.029) and used long term immunomodulator drugs more frequently (60.2% vs 47.3%; P=0.006) than UA patients. CD patients living in CA had more frequent ileo-colonic disease (L3) compared to inland patients (53.2% vs 38.0%, p=0.016). Patients with both UC and CD from inland areas needed immunomodulators or anti-TNF more frequently than coastal patients (56.7% vs 44.9%, p=0.026 and 82.1% vs 69.9%, p=0.023). CONCLUSION: IBD was more common among patients from inland, UA. Urban/rural or coastal/inland location did not affect gender, age at diagnosis or presence of EIM. However, UC patients from rural areas and CD patients from inland areas had more severe disease. | en_US |
dc.publisher | Sri Lanka Medical Association | en_US |
dc.subject | inflammatory bowel disease | en_US |
dc.title | Influence of urban/rural and coastal/inland environment on the phenotype and clinical course of inflammatory bowel disease patients from Sri Lanka: a cross-sectional study | en_US |
dc.type | Conference Abstract | en_US |
Appears in Collections: | Conference Papers |
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