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DC Field | Value | Language |
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dc.contributor.author | Warnakulasuriya, L.S. | - |
dc.contributor.author | Fernando, M.A.M. | - |
dc.contributor.author | Adikaram, A.V.N. | - |
dc.contributor.author | Thawfeek, A.R.M. | - |
dc.contributor.author | Anurasiri, W.M.L. | - |
dc.contributor.author | Silva, K.D.R.R. | - |
dc.contributor.author | Sirasa, M.S.F. | - |
dc.contributor.author | Samaranayake, D. | - |
dc.contributor.author | Wickramasinghe, V.P. | - |
dc.date.accessioned | 2017-09-12T09:37:04Z | - |
dc.date.available | 2017-09-12T09:37:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Sri Lanka Medical Association, 129th Anniversary International Medical Congress. 2016: 136 | en_US |
dc.identifier.issn | 0009-0895 | - |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/17417 | - |
dc.description | Oral Presentation Abstract (OP 56), 129th Anniversary International Medical Congress, Sri Lanka Medical Association, 25-27 July 2016 Colombo, Sri Lanka | en_US |
dc.description.abstract | INTRODUCTION: Childhood obesity-related metabolic derangements are increasing among South Asian populations. Dietary and physical activity plans have limited effect. OBJECTIVES: This study aims to assess effectiveness of metformin against placebo in management of childhood obesity among 8-16 year-old children in Gampaha District. METHOD: A triple-blinded control trial was conducted in a sample of 150 obese school children. After 12-hour overnight fast, blood was drawn for fasting blood glucose (FBS) and lipid profile. 2-hour OGTT was done. Anthropometry, fat mass (FM) and blood pressure were measured. Children randomly received either age-adjusted dose of metformin or placebo, with advice on diet and physical activity. Anthropometry and blood investigations were repeated at 6 and 12 months. Mean difference in outcome measures, adjusted for baseline values were compared between the two groups using ANOVA. RESULTS: There were 84/150 boys and 25 (16.7%) had metabolic syndrome. A statistically significant adjusted mean reduction was observed in metformin group compared to placebo, in weight (-0.991 vs 1.394, p=0.000), BMI-SDS (-0.287 vs -0.116, p=0.000), percentage FM-SDS (-0.092 vs 0.016, p=0.04), systolic BP (-0.415 vs 0.015, p=0.015), total cholesterol (-36.48 vs -27.32, p=0.001), LDL (-26.06 vs -17.22, p=0.001) and hsCRP(-0.143 vs 0.008, p=0.013) at six months, and in BMI-SDS (-370 vs -0.222, p=0.001), WC-SDS (-0.473 vs -0.337, p=0.018), systolic BP (-0.834 vs -0.477, p=0.023) and triglycerides (-29.30 vs-12,72, p=0.019) at 12 months. CONCLUSIONS: Metformin compared to placebo has beneficial effects on anthropometric and metabolic indicators in the management of childhood obesity. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Sri Lanka Medical Association | en_US |
dc.subject | Metformin | en_US |
dc.title | Metformin: use as a pharmacological agent in management of childhood obesity | en_US |
dc.type | Article | en_US |
Appears in Collections: | Conference Papers |
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