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Title: | Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo |
Authors: | Sunil-Chandra, N.P. Efstathiou, S. Nash, A.A. |
Keywords: | B-Lymphocytes-microbiology Herpesviridae-growth & development Herpesviridae-pathogenicity |
Issue Date: | 1992 |
Publisher: | Microbiology Society |
Citation: | Journal of General Virology. 1992; 73(12): 3275-3279. |
Abstract: | Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cellenriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein-Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/17180 |
ISSN: | 0022-1317 (Print) 1465-2099 (Electronic) 0022-1317 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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3275_1.pdf | 99.49 kB | Adobe PDF | View/Open |
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