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Title: | Treatment of lamivudine-resistant hepatitis B infection in post-renal transplant patients with Adefovir dipivoxil: preliminary results |
Authors: | de Silva, H.J. Dassanayake, A.S. Manamperi, A. de Silva, A.P. |
Issue Date: | 2006 |
Publisher: | Elsevier |
Citation: | Transplantation Proceedings. 2006; 38(9): 3118-120 |
Abstract: | We report the treatment outcome in six post-renal transplant patients with lamivudine-resistant hepatitis B virus (LR-HBV) infection using adefovir dipivoxil and followed for 6 to 18 months. Posttransplant immunosuppressive therapy was not altered. Adefovir dipivoxil effectively suppressed hepatitis B virus DNA and improved alanine transferase, although DNA suppression seemed dependent on continued therapy. Nephrotoxicity led to withdrawal of the drug in three patients. This may limit therapeutic usefulness in a significant proportion of post-renal transplant patients with LR-HBV infection. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1711 |
ISSN: | 0041-1345 (Print) 1873-2623 (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
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