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http://repository.kln.ac.lk/handle/123456789/17052
Title: | Sero-prevalence and vaccination status of hepatitis A and hepatitis B among adults with cirrhosis in Sri Lanka: a hospital based cohort study |
Authors: | Niriella, M.A. Kobbegala, V.J. Karalliyadda, H.N. Ranawaka, C.K. de Silva, A.P. Dassanayake, A.S. de Silva, H.J. |
Keywords: | Sero-prevalence |
Issue Date: | 2017 |
Publisher: | Biomed Central |
Citation: | BMC research notes. 2017; 10(1): 303 |
Abstract: | BACKGROUND: As acute viral hepatitis can be fatal in patients with cirrhosis, vaccination against hepatitis A (HAV) and hepatitis B (HBV) is recommended for non-immune patients. With increasing affluence the incidence of hepatitis A in childhood has decreased leading to a significant proportion of non-immune adults. As part of their routine investigation, hepatitis A IgG antibodies (anti-HAV IgG), hepatitis B surface antigen (HBsAg) and anti-HCV antibodies was checked and immunization status was assessed among consenting newly diagnosed cirrhotic patients presenting to a tertiary referral center. FINDINGS: Out of 135 patients, 107 [79.3%; males 91; mean age (SD) at presentation: 55.5 (11.6) years] with complete data were included for analysis. Most patients had either cryptogenic cirrhosis (62.6%) or alcoholic cirrhosis (29.9%); 2 (1.9%) had HBV cirrhosis, none had hepatitis C (HCV) cirrhosis. None of the patients had received vaccination against hepatitis A, while 71 (67.6%) had been vaccinated against HBV. The majority [62 (58%)] were negative for anti-HAV IgG. CONCLUSION: Most cirrhotic patients in this cohort were not immune to hepatitis A. None had been vaccinated against HAV, while a third of patients had not been vaccinated against HBV. Cirrhotic patients should be routinely investigated for immunity against HAV and HBV, and vaccination offered to those found to be non-immune. |
Description: | Indexed In MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/17052 |
ISSN: | 1756-0500 (Electronic) 1756-0500 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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biomed.2017.sero.pdf | 712.6 kB | Adobe PDF | View/Open |
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