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Title: Sequential studies on thyroid antibodies during pregnancy
Authors: Smyth, P.P.
Wijeyaratne, C.N.
Kaluarachi, W.N.
Smith, D.F.
Premawardena, L.D.K.E.
Parkes, A.B.
Jayasinghe, A.
de Silva, D.G.H.
Lazarus, J.H.
Issue Date: 2005
Publisher: Mary Ann Liebert Publishers
Citation: Thyroid. 2005; 15(5): pp.474-7
Abstract: Thyroid antibodies were measured sequentially in 25 pregnant women from a Sri Lankan population. A high prevalence of antithyroidantibodies, particularly antithyroglobulin antibodies (TgAb) had previously been demonstrated in female schoolchildren drawn from this population. In the present study TgAb were detected in 36.8% of nonpregnant controls while thyroid peroxidase antibody (TPOAb) positivity was present in 26.3%. The prevalence of both antibodies in the pregnancy study group showed a progressive decline compared to nonpregnant controls throughout gestation becoming undetectable in the third trimester. The results are consistent with an immunosuppressive effect of pregnancy in a population in whom high thyroid autoantibody titers may have resulted from a recent salt iodization program.
Description: Indexed in MEDLINE
ISSN: 1050-7256 (Print)
1557-9077 (Electronic)
Appears in Collections:Journal/Magazine Articles

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