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Title: Efficacy of rivastigmine on activities of daily living in Sri Lankan patients with Alzheimer disease and on improving caregiver burden: a prospective study
Authors: de Silva, H.A.
Pathmeswaran, A.
Gunatilake, S.B.
Keywords: Alzheimer Disease-diagnosis
Alzheimer Disease-diagnosis
Alzheimer Disease-drug therapy
Quality of Life
Controlled Clinical Trial
Single-Blind Method
Prospective Studies
Risk Assessment
Phenylcarbamates-administration and dosage
Issue Date: 2005
Publisher: Sri Lanka Medical Association
Citation: The Ceylon Medical Journal. 2005; 50(3): pp.106-109
Abstract: OBJECTIVE: This open label, parallel group, prospective cohort study investigated the efficacy of rivastigmine treatment on activities of dailyliving (ADL) in patients with mild to moderate Alzheimer's disease (AD) and the possible benefits of this therapy on caregiver stress levels. METHODS: Thirty eight consecutive patients with mild to moderate AD were recruited; 22 received rivastigmine 3-6 mg twice daily (treatment group) for 20 weeks. Sixteen patients who did not receive rivastigmine served as the control group. The 17-item ADL Index was used to assess ADL and to determine the presence of functional deterioration. Caregivers were evaluated with the Caregiver Stress Scale (CSS). Each patient was required to have a committed caregiver and all caregivers were interviewed and administered the ADL Index and the Caregiver Stress Scale (CSS) at the start of treatment (week 0) and at the end of 20 weeks of treatment (week 20). RESULTS: Patients in the control group showed a significant decline in ADL Index score at 20 weeks compared to rivastigmine-treatedpatients (difference in mean ADL Index score = 8.5; p < 0.001). At week 20, mean change from baseline scores for CSS total and individual domain scores were better for caregivers in the treatment group than those in the control group (CSS total mean difference = 19.2). CONCLUSION: We conclude that treatment of AD patients with rivastigmine for 20 weeks produces a significant improvement in patient ADL functioning, and lower levels of caregiver stress.
Description: Indexed in MEDLINE
ISSN: 0009-0875 (Print)
Appears in Collections:Journal/Magazine Articles

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