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dc.contributor.authorMalalavidhane, T.S.en_US
dc.contributor.authorWickremasinghe, S.M.D.N.en_US
dc.contributor.authorPerera, M.S.A.en_US
dc.contributor.authorJansz, E.R.en_US
dc.identifier.citationPhytotherapy Research. 2003; 17(9): pp.1098-1100en_US
dc.identifier.issn0951-418X (Print)en_US
dc.identifier.issn1099-1573 (Electronic)en_US
dc.descriptionIndexed in MEDLINE
dc.description.abstractIpomoea aquatica Forsk is a common green leafy vegetable consumed in many parts of the world. The present study was designed to investigate theoral hypoglycaemic activity of Ipomea aquatica in streptozotocin induced diabetic Wistar rats, and Type II diabetic patients. Experimental diabetes was induced with streptozotocin in Wistar rats. The rats were then divided into test and control groups. In addition to the standard feed given to both groups the test was fed with the shredded leaves of Ipomoea aquatica (3.4 g/kg) for one week. Type II diabetic patients were subjected to a glucose challenge before and after a single dose of blended I. aquatica. Patients acted as their own controls. The results revealed that consumption of the shredded, fresh, edible portion of I. aquatica for one week, effectively reduced the fasting blood sugar level of streptozotocin-induced diabetic rats (p = 0.01). When subjected to a glucose challenge, the Type II diabetic subjects showed a significant reduction (p = 0.001) in the serum glucose concentration 2 h after the glucose load. However, it was not significantly reduced at 1 h (p < 0.09) post glucose load. There was a 29.4% decrease in the serum glucose concentration of the diabetic patients when treated with the plant extract.en_US
dc.subjectBlood Glucose-drug effects
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetes Mellitus, Experimental-drug therapy
dc.subjectDiabetes Mellitus, Type 2-drug therapy
dc.subjectHypoglycemic Agents
dc.subjectHypoglycemic Agents-pharmacology
dc.subjectHypoglycemic Agents-therapeutic use
dc.subjectPlant Extracts
dc.subjectPlant Extracts-pharmacology
dc.subjectPlant Extracts-therapeutic use
dc.titleOral hypoglygaemic activity of Ipomea aquatica in streptozotocin induced diabetic wistar rats and type II diabeticsen_US
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