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DC Field | Value | Language |
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dc.contributor.author | Chandrasena, T.G.A.N. | en_US |
dc.contributor.author | Premaratna, R. | en_US |
dc.contributor.author | Abeyewickreme, W. | en_US |
dc.contributor.author | de Silva, N.R. | en_US |
dc.date.accessioned | 2014-10-29T09:19:22Z | |
dc.date.available | 2014-10-29T09:19:22Z | |
dc.date.issued | 2002 | en_US |
dc.identifier.citation | Transactions of the Royal Society of Tropical Medicine and Hygiene. 2002; 96(1): pp.60-63 | en_US |
dc.identifier.issn | 0035-9203 (Print) | en_US |
dc.identifier.issn | 1878-3503 (Electronic) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1496 | |
dc.description | Indexed in MEDLINE | |
dc.description.abstract | The sensitivity, specificity and cost effectiveness of an immunochromatographic card test (ICT, AMRAD) for the diagnosis of bancroftian filariasis were estimated against 2 standard parasitological techniques: thick blood film (TBF) and Nuclepore membrane filtration (NMF). Individuals were selected from endemic localities in the Western Province (n = 213) and from the non-endemic Central Province (n = 29) of Sri Lanka. Blood was collected between 21:00 and midnight. Sixty microlitre of non-heparinized blood, and 1 mL and 100 microL of heparinized blood were used in TBF, NMF andICT, respectively. NMF was positive in 31.5% (67/213) of the endemic group, with a mean microfilaria (mf) count of 343/mL (range 8-1782, SD 422). All 67 were positive by ICT (sensitivity 100%), but only 63 by TBF (sensitivity 94%). Among the endemic population there were 12 who were mf negative but antigen positive by ICT. There were, however, no false positives among the non-endemic controls, indicating the possibility that the ICTmay in fact be more sensitive and 100% specific. Thus, ICT filariasis test appears to be more effective (both sensitive and specific) than TBF or NMF in diagnosing infection in lymphatic filariasis. The direct unit recurrent costs of the 2 survey tools, TBF and ICT, were US$ 0.30 (Rs. 27/=) and US$ 2.75 (Rs. 248/=), respectively. The high cost of the ICT may be offset by other factors that are difficult to cost. | en_US |
dc.publisher | Oxford University Press | en_US |
dc.subject | Filariasis | en_US |
dc.subject | Clinical Trial | en_US |
dc.subject | Comparative Study | en_US |
dc.subject | Controlled Clinical Trial | en_US |
dc.subject | Antigens, Helminth-blood | en_US |
dc.subject | Cost-Benefit Analysis | en_US |
dc.subject | Filariasis-diagnosis | en_US |
dc.subject | Reagent Kits, Diagnostic-standards | en_US |
dc.subject | Wuchereria bancrofti-isolation and purification | en_US |
dc.title | Evaluation of the ICT whole-blood antigen card test to detect infection due to Wuchereria bancrofti in Sri Lanka | en_US |
dc.type | Article | en_US |
dc.identifier.department | Parasitology | en_US |
dc.identifier.department | Medicine | en_US |
dc.creator.corporateauthor | Royal Society of Tropical Medicine and Hygiene | en_US |
Appears in Collections: | Journal/Magazine Articles |
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