Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1474
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dc.contributor.authorNicholl, D.S.en_US
dc.contributor.authorDaniels, H.M.en_US
dc.contributor.authorThabrew, M.I.en_US
dc.contributor.authorGrayer, R.J.en_US
dc.contributor.authorSimmonds, M.S.J.en_US
dc.contributor.authorHughes, R.S.en_US
dc.date.accessioned2014-10-29T09:19:05Z
dc.date.available2014-10-29T09:19:05Z
dc.date.issued2001en_US
dc.identifier.citationJournal of Ethnopharmacology. 2001; 78(1): 39-44en_US
dc.identifier.issn0378-8741 (Print)en_US
dc.identifier.issn1872-7573 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/1474
dc.description.abstractAyruvedic medical practitioners in Sri Lanka use aqueous extracts of the mature leaves of Osbeckia aspera to treat liver disease. The extract has been shown to have hepatoprotective effects in vitro and in vivo, and to have inhibitory effects on the complement system and on in vitro phagocytosis by polymorphonuclear cells. The aim of this study was to investigate the effect of an aqueous extract of Osbeckia on lymphocyte proliferation stimulated by mitogens and antigen. In control peripheral blood mononuclear cells (PBMC), high concentrations of the Osbeckia extract were inhibitory to proliferation stimulated by phytohaemagglutinin (PHA) and tuberculin purified protein derivative (PPD). On stimulation by phorbol myristate acetate and ionomycin (PMA+I) the extract showed stimulation of proliferation at low concentrations (<10 microg/ml) with inhibition at higher concentrations. A similar inhibitory pattern on mitogen/antigen stimulation was seen with PBMC from patients with chronic hepatitis C virus (HCV) infection. These results suggest that the inhibitory agent(s) in the aqueous extract of Osbeckia may have an effect on antigen-presenting cell function. The combined hepatoprotective and immunosuppressive effects of the extract are more likely to be beneficial in acute hepatitis rather than chronic hepatitis viral infection.en_US
dc.publisherElsevieren_US
dc.subjectAdjuvants, Immunologic-pharmacologyen
dc.subjectHepatitis C, Chronic
dc.subjectHepatitis C, Chronic-immunology
dc.subjectHepatitis C, Chronic-pathology
dc.subjectLymphocytes-drug effectsen
dc.subjectMitogens-pharmacology Hepatitis C, Chronic / pathologyracts / pharmacology Plants, Medicinal / chemistry*
dc.subjectPlant Extracts
dc.subjectPlant Extracts-pharmacology
dc.subjectPlants, Medicinalen
dc.subjectPlants, Medicinal-chemistryen
dc.titleIn-vitro studies on the immunomodulatory effects of extracts of Osbeckia asperaen_US
dc.typeArticleen_US
dc.identifier.departmentBiochemistryen_US
dc.creator.corporateauthorInternational Society for Ethnopharmacologyen_US
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