Please use this identifier to cite or link to this item:
Title: Increased prevalence on thyroglobulin antibodies in Sri Lankan school girls - is iodine the cause?
Authors: Premawardena, L.D.K.E.
Parkes, A.B.
Smyth, P.P.A.
Wijeratne, C.N.
Jayasinghe, A.
de Silva, D.G.H.
Lazarus, J.H.
Keywords: Autoantibodies
Sodium Chloride, Dietary
Sodium Chloride, Dietary-adverse effects
Iodized salt
Iodine Iodine-adverse effects
Iodide Peroxidase
Issue Date: 2000
Publisher: BioScientifica Ltd.
Citation: European Journal of Endocrinology. 2000; 143(2): pp.185-188
Abstract: OBJECTIVE: Iodine deficiency was the likely cause of a high prevalence of goitre previously in Sri Lankan schoolchildren. Salt iodination was made compulsory in 1993 but there has been no recent study, using modern techniques, of its benefits or harmful effects. METHODS: Three hundred and sixty-seven schoolgirls between the ages of 11 and 16 years had ultrasound thyroid volume, free thyroxine (T4), free tri-iodothyronine (T3), thyrotrophin (TSH), anti-thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) antibodies, and urine iodine concentrations measured. RESULTS: Median ultrasound thyroid volume ranged from 4.8 ml (11-year-old girls) to 8.6 ml (16-year-old girls) with an age-related increase. Median urine iodine concentrations ranged from 105 to 152 microg/l. Free T4 and free T3 were normal in all, but TSH was elevated in four subjects (5. 53-41.29 mU/l). However, the prevalence of TgAb was markedly raised, ranging between 14.3% (11-year-old girls) and 69.7% (16-year-old girls) (P<0.03). In contrast, the prevalence of TPOAb was 10% or less in all age groups. CONCLUSIONS: Normal median thyroid volumes, iodine concentrations and thyroid function would indicate that iodine deficiency is not a major problem in this group. The high prevalence of TgAb, hitherto unreported, most likely reflects excessive iodination of Tg resulting in increased immunogenicity. There is an urgent need to continuously monitor the adequacy and risks of iodination in this population
Description: Indexed in MEDLINE
ISSN: 0804-4643 (Print)
1479-683X (Electronic)
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.