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DC Field | Value | Language |
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dc.contributor.author | Mettananda, K.C.D. | - |
dc.contributor.author | Danansuriya, D.S.T. | - |
dc.contributor.author | Bandara, N.K.B.K.R.G.W. | - |
dc.contributor.author | Premaratna, B.A.H.R. | - |
dc.date.accessioned | 2016-05-02T07:08:09Z | - |
dc.date.available | 2016-05-02T07:08:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Proceedings of the 25th Anniversary International Scientific Conference. Faculty of Medicine, University of Kelaniya; 2016: 89 | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/12837 | - |
dc.description | Free paper session 2: Infections OP 8 - 25th Anniversary International Scientific Conference, 6-8 April 2016, Faculty of Medicine,University of Kelaniya, Sri Lanka | en_US |
dc.description.abstract | Background: Place of infection in atherosclerosis and or coronary heart disease has recently drawn interest. Rickettsiae are a group of obligate intracellular pathogens who invade vascular endothelial cells leading to vasculopathy. A study conducted in Thaiwan, scrub typhus was found to increase the risk of acute coronary syndromes (ACS) by 37% compared to general population after adjusting for age, sex and other known independent risk factors. Objective: To assess the prevalence of Rickettsial infections in patients with ACS residing in Western province, Sri Lanka. Methods: Patients admitted with ACS to Professorial-Medical-unit, were studied for serological prevalence of Rickettsial infections and were compared with a matched control group; who had no fever or ACS. 2ml serum samples were obtained at enrolment and 2weeks after and were assessed for IFA-IgG antibody titres against Orientiatsutsugamushi (OT) and Spotted-fever-group-rickettsioses (SFG). An IgG titre>1:128 or a rising/declining titre were considered positive for acute rickettsioses. A static titre was considered to be due to previous exposure to rickettsioses. Results: 46 ACS patients (males-23.9%, mean age 61.1 [SD=13.1] years) and 52 controls (male-50%, mean age 56.0[SD=13.6] years) were studied. None had evidence of acute Rickettsiel infection. Sero-prevalence of IgG-OT was 6.4% and IgG-SFG was 15.2% among ACS patients. Same for control group were 3.8% and 11.5% respectively. There was no significant difference in sero-prevalence of OT [OR =0.74; CI: 0.28-10.93; p=0.66] or SFG [OR=1.376; CI:0.43-4.44; p=0.59] in patients with ACS compared to controls. Conclusions: No significant difference was observed in sero-prevalence of rickettsioses in patients with acute coronary syndromes compared to controls in this study. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Faculty of Medicine, University of Kelaniya, Sri Lanka | en_US |
dc.subject | rickettsial infections | en_US |
dc.title | Prevalence of rickettsial infections in acute coronary syndromes in Sri Lanka: a case control study | en_US |
dc.type | Article | en_US |
Appears in Collections: | 25th Anniversary International Scientific Conference-2016 |
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