Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/12783
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dc.contributor.authorPremawardhena, A.P.-
dc.date.accessioned2016-04-26T09:16:49Z-
dc.date.available2016-04-26T09:16:49Z-
dc.date.issued2016-
dc.identifier.citationProceedings of the 25th Anniversary International Scientific Conference. Faculty of Medicine, University of Kelaniya; 2016: 40en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/12783-
dc.descriptionSymposium A (SYM A): Haemoglobin disorders in Sri Lanka - 25th Anniversary International Scientific Conference, 6-8 April 2016, Faculty of Medicine,University of Kelaniya, Sri Lankaen_US
dc.description.abstractAlpha thalassaemia is one of the most common haemoglobinopathies, but the exact prevalence and distribution of α thalassaemia in Sri Lanka is not well known. This study was an attempt to micro-map the distribution of the common α thalassaemia deletions in Sri Lanka and to assess its contribution to hypochromic microcytosis in the community. A national survey on haemoglobin disorders was carried out between 2009 and 2010, covering all 25 districts. A total of 7539 school children, 300 from each district were screened for haemoglobin disorders and anaemia. 3.7 kb and 4.2 kb common α+ deletional forms were analysed using PCR in 2038 individuals with hypochromic microcytic anaemia and 1305 individuals with non-anaemia individuals, representing all districts. The overall prevalence of α-thalassaemia was 9.5%, and 3.7 kb was the commonest deletion (8.3%) while the 4.2 kb deletion accounted for 1.2%. The prevalence of α-thalassaemia showed a remarkable variability within districts, ranging from 16.3% in Kurunegala to 3.0% in Galle. Contrary to common belief, it was found that α-thalassaemia due to single gene deletions was almost always associated with hypochromic microcytic anaemia.en_US
dc.language.isoen_USen_US
dc.publisherFaculty of Medicine, University of Kelaniya, Sri Lankaen_US
dc.subjectthalassaemiaen_US
dc.titleMicro-mapping of common α+ thalassaemia deletions (3.7 kb, 4.2 kb) in Sri Lanka and assessment of the contribution of α thalassaemia to hypochromic microcytosisen_US
dc.typeArticleen_US
Appears in Collections:25th Anniversary International Scientific Conference-2016

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