Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/127
Title: Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin
Authors: Wijesooriya, W.R.P.L.I.
Kotsanas, D.N.
Korman, T.M.
Graham, M.
Keywords: Coagulase-negative staphylococci
Issue Date: 2017
Publisher: Sri Lankan Society for Microbiology
Citation: Sri Lankan Journal of Infectious Diseases. 2017; 7(1): 10 –17
Abstract: INTRODUCTION AND OBJECTIVES: Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012. METHODS: All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU). RESULTS: Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. Staphylococcus epidermidis was the most common species recovered and was more likely to be Teico-NS. CONCLUSIONS: Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains.
URI: http://repository.kln.ac.lk/handle/123456789/127
ISSN: 2448-9654(Electronic)
Appears in Collections:Journal/Magazine Articles

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