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Title: | Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
Authors: | Wijesooriya, W.R.P.L.I. Kotsanas, D.N. Korman, T.M. Graham, M. |
Keywords: | Coagulase-negative staphylococci |
Issue Date: | 2017 |
Publisher: | Sri Lankan Society for Microbiology |
Citation: | Sri Lankan Journal of Infectious Diseases. 2017; 7(1): 10 –17 |
Abstract: | INTRODUCTION AND OBJECTIVES: Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012. METHODS: All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU). RESULTS: Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. Staphylococcus epidermidis was the most common species recovered and was more likely to be Teico-NS. CONCLUSIONS: Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains. |
URI: | http://repository.kln.ac.lk/handle/123456789/127 |
ISSN: | 2448-9654(Electronic) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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sljol.2017.teico.pdf | 419.98 kB | Adobe PDF | View/Open |
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