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Title: | Protective effect of vitamin E in kidney storage solution on renal tissue metabolism in rats |
Authors: | Selliah, S. de Mel, T. Hewamadduma, C.A.A. de Tissera, A. |
Keywords: | Gluconeogenesis-drug effects Kidney-metabolism Organ Preservation Vitamin E-pharmacology |
Issue Date: | 1995 |
Publisher: | Sri Lanka Medical Association |
Citation: | The Ceylon Medical Journal. 1995; 40(2): pp.97-100 |
Abstract: | OBJECTIVE:To determine whether inclusion of vitamin E into kidney storage solutions protects metabolism and tubular ultrastructure of stored rat kidney. METHODS: Rat kidneys were flush stored in Marshall's Citrate (MC) and MC + vitamin E (25% of LD 50 and 50% of LD 50) for 24 hours at 0 degrees C. After storage kidney slices were tested for gluconeogenesis and lactate dehydrogenase (LDH) activity, and examined for cellular ultrastructure. RESULTS: Kidneys stored in MC + vitamin E gave higher gluconeogenesis than those stored in MC alone (p < 0.001). Tubular ultrastructure was better preserved in the presence of Vitamin E. CONCLUSIONS: Vitamin E appears to protect the metabolism and ultrastructure of stored rat kidneys. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1252 |
ISSN: | 0009-0875 (Print) |
Appears in Collections: | Journal/Magazine Articles |
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