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Title: Clostridium difficile infection in inflammatory bowel disease patients in Sri Lanka
Authors: Waraketiya, P.R.
de Silva, A.P.
Wijesinghe, N.T.
Waraketiya, P.R.
Wijewantha, H.S.
Chandrasena, L.G.
Pathmeswaran, A.
de Silva, H.J.
Keywords: Clostridium difficile infection
Issue Date: 2012
Publisher: Sri Lanka Medical Association
Citation: Sri Lanka Medical Association, 125th International Medical Congress. 2012;57 Suppliment1: 150
Abstract: INTRODUCTION: Over the last decade an increase in Clostridium difficile associated diarrhoea (CDAD) has been observed among Caucasians (1%). The frequency of CDAD is very high in Caucasian IBD patients; 8.7% in one study of IBD patients in remission. This has led to guidelines recommending routine screening for CDAD in IBD. Clinical impressions are that CDAD is rare among Sri Lankans. AIMS: This study was conducted to determine the frequency of CDAD in a cohort of Sri Lankan IBD patients and healthy controls. METHODS: Cases [n=154] were histologically confirmed IBD patients, in clinical remission. The controls [n=100) were non-IBD patients who presented to medical clinics without diarrhoea and with no exposure to antibiotics for up to 8 weeks prior to recruitment. Immunoassays for Clostridium difficile toxins A and B were performed on stool samples obtained from both groups. RESULTS: The frequency of CDAD was 0.7% (n=l) and 0% (n=0) in IBD patients and controls respectively. CONCLUSIONS: Compared to Caucasians, CDAD was very rare in this cohort of Sri Lankans, including those with IBD. Routine screening for CDAD does not seem necessary in our setting.
Description: Poster Presentation Abstract (PP 163), 125th Anniversary Scientific Medical Congress, Sri Lanka Medical Association, June 2012 Colombo, Sri Lanka
ISSN: 0009-0895
Appears in Collections:Conference Papers

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