Please use this identifier to cite or link to this item:
Title: A study to determine quantitative predictors for development of third space fluid accumulation in adult patients with dengue
Authors: Premaratna, R.
Ragupathy, A.
Miththinda, J.K.N.D.
de Silva, H.J.
Keywords: dengue
Issue Date: 2012
Publisher: Sri Lanka Medical Association
Citation: Sri Lanka Medical Association, 125th International Medical Congress. 2012;57 Suppliment1: 109
Abstract: INTRODUCTION: Prediction of severe illness remains the most important measure in preventing mortality associated with dengue. Increased vascular permeability leading to reduced intravascular volume is the hallmark of dengue shock syndrome. Third space fluid accumulation (TSFA) reflects severe vascular permeability and therefore, it is important to quantitatively identify parameters which predict the occurrence of TSFA in dengue. METHODS:102 patients with confirmed dengue were prospectively followed up for clinical, haematological, biochemical parameters and for evidence of TSFA by serial utrasonography. These parameters were tested against development of TSFA using Receiver Operating Characteristic [ROC] curves to identify quantitative predictors of development of TSFA. RESULTS: 102 patients (52 males) with mean age 28.3 years (SD 11.8), TSFA was detected in 34/95 [36%) after admission; 21/95 developed ascites at mean 5.7 days of illness (SD 1.3) and 33/95 had pleural effusion at 5.4 days (SD 1.5). Onset of TSFA could be identified using percentage rises of highest PCV (p= 0.002) where 6.5% rise of PCV predicted TSFA(sensitivity 61%, specificity 62%)], highest Hb (p=0.017) where rise of 6.1% in Hb predicted TSFA (sensitivity 55%, specificity 64%), lowest recorded platelet count (p<0.000) where platelet count of 48500/mm3 or less predicted TSFA (sensitivity of 83%, specificity 51) post-admission fluid input-output balance per day (p 0.002) where positive balance more than 777cc/day predicted TSFA (sensitivity 65%, specificity 64%). CONCLUSIONS: Rise of PCV and Hb, platelet count, WBC count and daily fluid balance appear to be useful quantitative predictors of TSFA in dengue.
Description: Poster Presentation Abstract (PP 79), 125th Anniversary Scientific Medical Congress, Sri Lanka Medical Association, June 2012 Colombo, Sri Lanka
ISSN: 0009-0895
Appears in Collections:Conference Papers

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.