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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Patel, R.T. | en_US |
dc.contributor.author | Deen, K.I. | en_US |
dc.contributor.author | Youngs, D. | en_US |
dc.contributor.author | Warwick, J. | en_US |
dc.contributor.author | Keighley, M.R. | en_US |
dc.date.accessioned | 2014-10-29T09:11:34Z | - |
dc.date.available | 2014-10-29T09:11:34Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | British Journal of Surgery. 1994; 81(9): pp.1306-08 | en_US |
dc.identifier.issn | 0007-1323 (Print) | en_US |
dc.identifier.issn | 1365-2168 (Electronic) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1220 | - |
dc.description | Indexed in MEDLINE | - |
dc.description.abstract | Levels of plasma cytokines and circulating endotoxin were assessed in 41 patients with severe intra-abdominal sepsis. Comparison was made with the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system. Blood samples were taken within 24 h of onset of the sepsis syndrome and at serial times thereafter. Increased levels of interleukin (IL) 6 (range 50-25,500 pg/ml) were detectable in all patients with sepsis. Eighteen of the 19 deaths were attributable to sepsis and higher levels of IL-6 at the onset of the sepsis syndrome correlated with a poor outcome. The sensitivity of IL-6 concentration in predicting mortality was 86.4 per cent with a specificity of 78.9 per cent and an overall correct classification rate of 82.9 per cent. IL-6 level was a better predictor than APACHE II score (sensitivity 72.7 per cent, specificity 57.9 per cent, correct classification rate 65.9 per cent). Levels of tumour necrosis factor alpha, IL-1 beta and endotoxin did not correlate with mortality rate. Plasma IL-6 concentrations may help in planning future strategies to decrease the mortality rate associated with sepsis. | en_US |
dc.subject | Bacterial Infections | - |
dc.subject | Bacterial Infections-mortality | - |
dc.subject | Endotoxins-blood | - |
dc.subject | Interleukin-1-blood | - |
dc.subject | Interleukin-6-blood | - |
dc.subject | Risk Factors | - |
dc.subject | Tumor Necrosis Factor | - |
dc.title | Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis | en_US |
dc.type | Article | en_US |
dc.identifier.department | Surgery | en_US |
Appears in Collections: | Journal/Magazine Articles |
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