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Title: Absence of anti-Purkinje cell antibodies in patients with cerebellar ataxia following falciparum malaria
Authors: de Silva, H.J.
Senanayake, N.
Keywords: Malaria
Malaria, Cerebral
Malaria, Cerebral-immunology
Malaria, Cerebral-diagnosis
Malaria, Falciparum
Malaria, Falciparum-diagnosis
Malaria, Falciparum-immunology
Purkinje Cells-immunology
Autoantibodies-cerebrospinal fluid
Cerebellar Ataxia-immunology
Issue Date: 1994
Publisher: SEAMEO Regional Tropical Medicine and Public Health Project
Citation: The Southeast Asian Journal of Tropical Medicine and Public Health. 1994; 25(4): pp.707-709
Abstract: Immunological mechanisms have been implicated in the pathogenesis of delayed cerebellar ataxia following falciparum malaria (DCA). We tested serum and CSF samples obtained from 39 Sri Lankan patients with DCA for the presence of antibodies (Ab) directed against cerebellar Purkinje cells by an immunofluorescence (IF) technique and Western blot analysis. For the IF test 7 mu thick frozen sections of histologically normal cerebellum obtained at post mortem were used. Proteins obtained from crude preparations of Purkinje cells isolated from the cerebellum were used for Western blot analysis. Sera obtained from patients known to have antineuronal antibodies associated with cerebellar degenerations and paraneoplastic disorders (anti-Hu and anti-Yo Ab) and sera from normal blood donors served as positive and negative controls, respectively. All serum and CSF samples obtained from patients with DCA were negative for Ab directed against cerebellar Purkinje cells. Humoral mechanisms are, therefore, unlikely to be important in the pathogenesis of this delayed complication of falciparum malaria.
Description: Indexed in MEDLINE
Appears in Collections:Journal/Magazine Articles

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