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DC Field | Value | Language |
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dc.contributor.author | Eddleston, M. | en |
dc.contributor.author | Juszczak, E. | en |
dc.contributor.author | Buckley, N.A. | en |
dc.contributor.author | Senarathna, L. | en |
dc.contributor.author | Mohamed, F. | en |
dc.contributor.author | Dissanayake, W. | en |
dc.contributor.author | Hittarage, A. | en |
dc.contributor.author | Azher, S. | en |
dc.contributor.author | Jeganathan, K. | en |
dc.contributor.author | Jayamanne, S. | en |
dc.contributor.author | Sheriff, M.R. | en |
dc.contributor.author | Warrell, D.A. | en |
dc.contributor.author | Ox-Col Poisoning Study collaborators | en |
dc.date.accessioned | 2016-01-29T06:11:27Z | en |
dc.date.available | 2016-01-29T06:11:27Z | en |
dc.date.issued | 2008 | en |
dc.identifier.citation | Lancet.2008;371(9612):579-87 | en_US |
dc.identifier.issn | 0140-6736 (Print) | |
dc.identifier.issn | 1474-547X (Electronic) | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/11464 | |
dc.description.abstract | BACKGROUND: The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefore aimed to assess whether routine treatment with multiple-dose activated charcoal, to interrupt enterovascular or enterohepatic circulations, offers benefit compared with no charcoal in such an environment. METHODS: We did an open-label, parallel group, randomised, controlled trial of six 50 g doses of activated charcoal at 4-h intervals versus no charcoal versus one 50 g dose of activated charcoal in three Sri Lankan hospitals. 4632 patients were randomised to receive no charcoal (n=1554), one dose of charcoal (n=1545), or six doses of charcoal (n=1533); outcomes were available for 4629 patients. 2338 (51%) individuals had ingested pesticides, whereas 1647 (36%) had ingested yellow oleander (Thevetia peruviana) seeds. Mortality was the primary outcome measure. Analysis was by intention to treat. The trial is registered with controlled-trials.com as ISRCTN02920054. FINDINGS: Mortality did not differ between the groups. 97 (6.3%) of 1531 participants in the multiple-dosegroup died, compared with 105 (6.8%) of 1554 in the no charcoal group (adjusted odds ratio 0.96, 95% CI 0.70-1.33). No differences were noted for patients who took particular poisons, were severely ill on admission, or who presented early. INTERPRETATION: We cannot recommend the routine use of multiple-dose activated charcoal in rural Asia Pacific; although further studies of early charcoal administration might be useful, effective affordable treatments are urgently needed. Comment in : Is this the epitaph for multiple-dose activated charcoal? [Lancet. 2008] | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Lancet Publishing Group | en_US |
dc.subject | self-poisoning | en_US |
dc.title | Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
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