Please use this identifier to cite or link to this item:
http://repository.kln.ac.lk/handle/123456789/1145
Title: | Mucosal characteristics of pelvic ileal pouches |
Authors: | de Silva, H.J. Millard, P.R. Kettlewell, M. Mortensen, N.J. Prince, C. Jewell, D.P. |
Keywords: | Ileitis-pathology Ileum-metabolism Ileum-pathology Ileum-surgery Intestinal Mucosa-metabolism Intestinal Mucosa-pathology Adenomatous Polyposis Coli-surgery Anal Canal-surgery Anastomosis, Surgical Colitis, Ulcerative-surgery Colon-surgery Sucrase-Isomaltase Complex-metabolism |
Issue Date: | 1991 |
Publisher: | British Medical Assosiation |
Citation: | Gut. 1991; 32(1): pp.61-65 |
Abstract: | This study aimed to investigate the degree of colonic metaplasia in ileo - anal pouches. Biopsy specimens from 25 patients with functioning pouches, eight of whom had pouchitis, were studied using routine histology, mucosal morphometry, mucin histochemistry, and immunoperoxidase staining with monoclonal antibodies directed towards a 40kD colonic protein and a small bowel specific disaccharidase-sucrase isomaltase. Thirteen patients (including all eight with pouchitis) had subtotal or total villous atrophy and crypt hyperplasia. In this group, nine had colorectal type sulphomucin and the 40kD colonic protein was detected in two. These changes were not observed in patients with less severe villous abnormalities. Sucrase-isomaltase activity was, however, present in all 25 pouch specimens. We conclude that although some ileal pouches acquire certain colonic characteristics, complete colonic metaplasia does not occur. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1145 |
ISSN: | 0017-5749 (Print) 1468-3288 (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.