Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity

Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1133

Title:	Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity
Authors:	Jayathilake, K.A. Thabrew, M.I. Perera, D.J.
Keywords:	Plant Extracts Plant Extracts-pharmacology Pharmaceutical Preparations-metabolism- Carbon Tetrachloride-toxicity Lipid Peroxidation/drug effects Microsomes, Liver-enzymology Mixed Function Oxygenases-metabolism
Issue Date:	1990
Publisher:	Elsevier
Citation:	Journal of Ethnopharmacology. 1990; 30(1): pp.97-105
Abstract:	Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the enzymes.
Description:	Indexed in MEDLINE
URI:	http://repository.kln.ac.lk/handle/123456789/1133
ISSN:	0378-8741 (Print) 1872-7573 (Electronic)
Appears in Collections:	Journal/Magazine Articles

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