Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1125
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dc.contributor.authorJayathilake, K.A.en_US
dc.contributor.authorThabrew, M.I.en_US
dc.contributor.authorPathirana, C.en_US
dc.contributor.authorde Silva, D.G.H.en_US
dc.contributor.authorPerera, D.J.en_US
dc.date.accessioned2014-10-29T09:10:03Z
dc.date.available2014-10-29T09:10:03Z
dc.date.issued1989en_US
dc.identifier.citationPlanta Medica. 1989; 55(2): pp.137-139en_US
dc.identifier.issn0032-0943 (Print)en_US
dc.identifier.issn1439-0221 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/1125
dc.descriptionIndexed in MEDLINE
dc.description.abstractAqueous extracts of the aerial parts of Melothria maderasptana and the leaves of Osbeckia octandra have been compared with (+)-3-cyanidanol with regard to their abilities to alleviate carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by comparing the abilities of these drugs to protect the liver against CCl4-mediated alterations in the liver histopathology and serum levels of aspartate aminotransferase (GOT), alkaline amino-transferase (GPT), and alkaline phosphatase. In both pretreatment and post-treatment (administration of drugs before or after CCl4 treatment) experiments, the most marked rate of recovery of the liver was exhibited by the group of rats treated with Melothria maderaspatana extract. Although the protection offered by (+)-3-cyanidanol and Osbeckia octandra appears to be comparable in post-treatment, Osbeckia was significantly more effective in pre-treatment. From the overall results obtained it appears that the aqueous extracts of Melothria maderaspatana and Osbeckia octandra are both as potent or in some instances (in pretreatment experiments) more potent than (+)-3-cyanidanol. Of the two plants tested under the present experimental conditions used, Melothria maderaspatana appears to be marginally more effective than Osbeckia octandra in protecting the liver against CCl4-induced alterations.
dc.publisherGeorge Thiemeen_US
dc.subjectPlant Extracts
dc.subjectPlant Extracts-pharmacology
dc.subjectLiver Diseases-drug therapy
dc.titleAn Evaluation of the potency of Osbeckia octandra and Melothria maderaspantana as antihepatotoxic agents.en_US
dc.typeArticleen_US
dc.identifier.departmentBiochemistryen_US
dc.identifier.departmentPaediatricsen_US
dc.creator.corporateauthorDeutsche Gesellschaft fur Arzneipflanzenforschungen_US
dc.creator.corporateauthorGesellschaft fur Arzneipflanzenforschung (Germany)en_US
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