Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/10951
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dc.contributor.authorRanawaka, C.K.en_US
dc.contributor.authorKumarasena, R.S.en_US
dc.contributor.authorNiriella, M.A.en_US
dc.contributor.authorMiththinda, J.K.N.D.en_US
dc.contributor.authorPathmeswaran, A.en_US
dc.contributor.authorDassanayake, A.S.en_US
dc.contributor.authorde Silva, A.P.en_US
dc.contributor.authorPremaratna, R.en_US
dc.contributor.authorde Silva, H.J.en_US
dc.date.accessioned2015-12-24T13:13:37Zen_US
dc.date.available2015-12-24T13:13:37Zen_US
dc.date.issued2012en_US
dc.identifier.citationJournal of Gastroenterology and Hepatology. 2012; 27(Supp 5): 226en_US
dc.identifier.issn0815-9319 (Print)en_US
dc.identifier.issn1440-1746 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/10951en_US
dc.descriptionPoster Session Abstract (P11-74), 22nd Asian Pacific Digestive Week, December 5–8, 2012, Bangkok, Thailanden_US
dc.description.abstractBACKGROUND AND AIM: Dengue infections (DI) have a diverse clinical spectrum ranging from asymptomatic illness to severe dengue. Unusual manifestations such as encephalitis, myocarditis, and acute liver failure (ALF) are increasingly recognized. Though ALF is less common has a poor prognosis. Aim of this study was to identify possible predictors of ALF in DI. METHOD: Serologically confirmed patients with DI, admitted to university medical unit, Ragama, Sri Lanka from January 2009 to March 2010 were included. Patients were consisted of direct admission as well as referrals with deranged liver functions. Data was obtained from patient records. RESULTS AND DISCUSSION: Out of 240 patients (male : female 57.7%:42.5%; mean age 35.6 years [SD 15.4 years]), 164 had dengue with warning signs, 27 had dengue without warning signs and 49 had severe dengue. 15/49 severe dengue patients had profound shock. Abdominal pain, persistent vomiting (PV), bleeding, hepatomegaly and ascites were present in 125, 92, 39,129 and 28 cases respectively. Elevated AST/ALT, serum bilirubin (SB), alkaline phosphatase (ALP) and gamma glutamyl transpeptide (GGT) were observed in 208, 20, 18 and 60 patients respectively. Of the 240 patients 41 had AST/ALT > 1000 IU/ml and 199 had AST/ALT < 1000 IU/ml. Only 16/41 patients with AST/ALT > 1000 IU/ml developed ALF while none from the AST/ALT < 1000 IU/ml group. Only 4/15 of profound shock had ALF. Patients with AST/ALT > 1000 IU/ml, presence of 2 or 3 of; elevated SB, elevated ALP or PV predicted the development of ALF with 93.8% sensitivity, 98.7% specificity, 83.3% positive predictive value (PPV) and 99% negative predictive value (NPV) with p < 0.001. CONCLUSIONS: Dengue patients who’s AST/ALT < 1000 IU/ml, excluded patients at risk of ALF. Presence of 2 or 3 of: PV, elevated SB or elevated ALP in a patient with AST/ALT > 1000 IU/ml may indicate impending ALF. This needs further validation in a larger populationen_US
dc.language.isoen_USen_US
dc.publisherWiley Blackwell Scientific Publicationsen_US
dc.subjectLiver Diseasesen_US
dc.subjectDengueen_US
dc.subjectSevere Dengueen_US
dc.subjectLiver Failure, Acuteen_US
dc.titlePredicting acute liver failure in dengue infectionen_US
dc.typeConference Abstracten_US
dc.creator.corporateauthorAsian Pacific Association of Gastroenterologyen
dc.creator.corporateauthorAsian Pacific Association for the Study of the Liveren_US
Appears in Collections:Conference Papers

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