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Title: Development and validation of Sinhala version of the chronic liver disease questionnaire (CLDQ)
Authors: Miththinda, J.K.N.D.
Ranawaka, C.
Pathmeswaran, A.
Dassanayake, A.S.
de Alwis, W.R.S.
Mufeena, M.N.F.
Senanayake, S.M.
Niriella, M.A.
de Silva, A.P.
de Silva, H.J.
Keywords: Liver Diseases
Liver Diseases-diagnosis
Validation Studies
Surveys and Questionnaires-standards
Liver Cirrhosis
Issue Date: 2013
Publisher: Wiley Blackwell Scientific Publications
Citation: Journal of Gastroenterology and Hepatology. 2013; 28(Suppl 3):178
Abstract: OBJECTIVE: The Chronic Liver Disease Questionnaire (CLDQ) is a validated tool measuring the Health Related Quality of Life among cirrhotics. Aim of this study was to develop and validate a Sinhala version of the CLDQ (sCLDQ) and to test its correlation with the degree of liver dysfunction in a cohort of Sri Lankan patients with cirrhosis. METHODS: A standard translation method was used to develop the sCLDQ. Pilot testing was done with relevant cultural and language adaptations. The final version was self-administered to stable CLD patients, together with the WHO Quality of Life-BREF (WHOQOL-BREF) validated Sinhala version, for comparison. sCLDQ was re administered 4 weeks later to test internal consistency and reliability. The validation was assessed by Cronabach’s alpha, intraclass correlation coefficient (ICC) and Pearson’s correlation coefficient. ANOVA and Pearson’s correlation were used to test correlation with the degree of liver dysfunction. RESULTS: Validation was done with 214 subjects, mean age 55.6 (SD 10.4) years; male 77.6%. Overall Cronabach’s alpha was 0.926. Itra-class correlations varied from 0.431 to 0.912 and all were significant (p 0.000). Retesting was done on a sub-sample of 18 subjects. Test-retest correlation was 0.695 (p 0.008). WHO-BREF was applied on a sub-sample of 48 subjects. There was a significant correlation (Pearson’s r = 0.391; p = 0.004) between sCLDQ and WHOQOL BREF. sCLDQ was significantly associated with MELD (r = −0.13; p = 0.038), MELD Sodium (r = −0.223; p = 0.002), Bilirubin (r = −0.124; p = 0.036), Serum Sodium (r = 0.172; p = 0.009), Serum Albumin (r = 0.201; p = 0.003) and Child grade (f = 3.687; p = 0.027). CONCLUSION: sCLDQ is a reliable and valid tool to assess QoL of Sri Lankan cirrhotics and correlates well with known indices of disease severity.
Description: Poster Session Abstract (P0407), Gastro 2013 APDW/WCOG Shanghai, Asian Pacific Digestive Week 2013 / World Congress of Gastroenterology, September 21–24, 2013, Shanghai Expo Center, Shanghai, China
ISSN: 0815-9319 (Print)
1440-1746 (Electronic)
Appears in Collections:Conference Papers

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