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Title: | Oro-caecal transit in Sri Lankan children and adolescents with functional recurrent abdominal pain |
Authors: | Devanarayana, N.M. de Silva, D.G.H. de Silva, H.J. |
Keywords: | Gastrointestinal Diseases Abdominal Pain Abdominal Pain-physiopathology Gastrointestinal Motility Gastrointestinal Transit Gastrointestinal Transit-physiology Intestine, Small-physiology Cecum-physiology Child |
Issue Date: | 2008 |
Publisher: | Wiley Blackwell Scientific Publications |
Citation: | Journal of Gastroenterology and Hepatology. 2008; 23(Suppl 5): A157 |
Abstract: | INTRODUCTION: Recurrent abdominal pain (RAP) is a common paediatric problem. The majority of the affected have no organic pathology. Gastrointestinal motility abnormalities are considered as a possible cause for their symptoms. This study evaluated oro-caecal transit in children and adolescents with functional RAP. METHODS: Thirty one children with functional RAP and 20 healthy children from the same geographical area underwent oro-caecal transit time measurement by lactulose (0.25 g/kg in 10% solution) breath hydrogen test. None had evidence of organic disease, except for one control who had a positive Helicobacter pylori stool antigen test. RESULTS: Oro-caecal transit times could be calculated in 30 patients [10 (33.3%) males, mean age 7.2 years, SD 2.4 years, 12 functional abdominal pain, 8 irritable bowel syndrome, 8 functional dyspepsia, 1 abdominal migraine, 1 non-specific abdominal pain according to Rome III criteria] and 19 controls [10 (52.6%) males, mean age 9 years, SD 2.7 years]. One patient (3%) and 1 control (5%) were non-responders. Oro-caecal transit time was significantly prolonged in patients (median 90 min, range 45–150 min) compared to controls (median 75 min, range 30–105 min) (p = 0.0045). Oro-caecal transit time did not correlate with scores obtained for severity of abdominal pain (r = 0.176, p = 0.354) and had no association with exposure to recent stressful life events (p > 0.05). CONCLUSIONS: Oro-caecal transit time was delayed in children and adolescents with functional RAP. The future studies are needed to confirm the role of delayed oro-caecal transit in generation of symptoms, and to evaluate the therapeutic value of drugs that normalize small intestinal transit. |
Description: | Poster Session Abstract (No.92), Asian Pacific Digestive Week, September 13–16, 2008, New Delhi, India |
URI: | http://repository.kln.ac.lk/handle/123456789/10935 |
ISSN: | 0815-9319 (Print) 1440-1746 (Electronic) |
Appears in Collections: | Conference Papers |
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