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Title: | Histopathological spectrum in acute and chronic Cutaneous Leishmaniasis in Sri Lanka |
Authors: | Manamperi, N.H. Fernando, C. Pathirana, K.P.N. Karunaweera, N.D. Abeyewickreme, W. de Silva, M.V.C. |
Keywords: | Histopathological spectrum |
Issue Date: | 2015 |
Publisher: | Sri lanka Medical Association |
Citation: | Proceedings of the Sri Lanka Medical Association, Anniversary Academic Sessions. 2015; 128: 236 |
Abstract: | INTRODUCTION AND OBJECTIVES: Histological spectrum in cutaneous leishmaniasis (CL) is wide and varied. The objective of this study is to describe the histological spectrum of acute and chronic CL. METHOD: Skin biopsies of 35 patients with smear positive for Leishmania amastigotes were processed routinely for histopathology, examined at a conference microscope and classified into 4 groups using modified Ridley criteria for Leishmaniasis as: I- parasitized macrophages with variable lymphocytes and plasma ceils; 1! - parasitized macrophages with lymphocytes, plasma cells and ill formed histiocytic granulomata; 111 - a mixture of macrophages (with or without parasites), lymphocytes, plasma cells and epithelioid granulomata; IV - epithelioid granulomatous response with a few lymphocytes and plasma cells but no amastigotes. Lesions were categorized as acute (< 6 months) or chronic (> 6 months). RESULTS: Study group composed of all males with a mean age of 32.6 years (range 22 - 47) and lesion duration of 5.6 months (range 1-24). Twenty nine (82.9%) were also positive by histopathology. Twenty two (62.9%) were acute and 13 (37.1%) chronic. Group I, II, Ml and IV patterns were seen in 14 (40%), 12 (34.3%), 5 (14.3%) and 4 (11.4%) respectively and 9 (40.9%), 9 (40.9%), 2 (9.1%) and 2 (9.1%) of acute lesions and 5 (38.5%), 3 (23.1%), 3 (23.1%) and 2 (15.4%) of chronic lesions respectively. CONCLUSION: Histology of CL shows marked inflammatory cell infiltrate with or without granuloma formation. Majority of patients presenting with either acute or chronic CL belong to histological groups I or II. |
Description: | Poster Presentation Abstract (PP140), 128th Annual Scientific Sessions, Sri Lanka Medical Association, 6th-8th July 2015 Colombo, Sri Lanka |
URI: | http://repository.kln.ac.lk/handle/123456789/10693 |
Appears in Collections: | Conference Papers |
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