Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/10245
Title: Early course of inflammatory bowel disease in a population-based Inception cohort study from 8 countries in Asia and Australia
Authors: Ng, S.C.
Zeng, Z.
Niewiadomski, O.
Tang, W.
Bell, S.
Kamm, M.A.
Hu, P.
de Silva, H.J.
Niriella, M.A.
Udara, W.Y.
Ong, D.
Ling, K.L.
Ooi, C.J.
Hilmi, I.
Goh, K.L.
Ouyang, Q.
Wang, Y.F.
Wu, K.
Wang, X.
Pisespongsa, P.
Manatsathit, S.
Aniwan, S.
Limsrivilai, J.
Gunawan, J.
Simadibrata, M.
Abdullah, M.
Tsang, S.W.
Lo, F.H.
Hui, A.
Chow, C.M.
Yu, H.H.
Li, M.F.
Ng, K.K.
Ching, J.Y.
Chan, V.
Wu, J.C.
Chan, F.K.
Chen, M.
Sung, J.J.
Asia-Pacific Crohn's and Colitis Epidemiology Study (ACCESS) Group
Keywords: Inflammatory Bowel Disease
Issue Date: 2016
Publisher: Baltimore
Citation: Gastroenterology. 2016; 150(1): 86-95.e3
Abstract: Background & Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Asia, but little is known about disease progression in this region. The Asia-Pacific Crohn’s and Colitis Epidemiology Study was initiated in 2011, enrolling subjects from 8 countries in Asia (China, Hong Kong, Indonesia, Sri Lanka, Macau, Malaysia, Singapore, and Thailand) and Australia. We present data from this ongoing study. Methods: We collected data on 413 patients diagnosed with IBD (222 with ulcerative colitis [UC)], 181 with Crohn’s disease [CD], 10 IBD unclassified [IBDU]; median age, 37 years) from 2011 through 2013. We analyzed disease course and severity and mortality. Risks for medical and surgical therapies were assessed using Kaplan-Meier analysis. Results: The cumulative probability that CD would change from inflammatory to stricturing or penetrating disease was 19.6%. The cumulative probabilities for use of immunosuppressants or anti-tumor necrosis factor (TNF) agents were 58.9% and 12.0% for patients with CD, and 12.7% and 0.9% for patients with UC, respectively. Perianal CD was associated with an increased risk of anti-TNF therapy within 1 year of its diagnosis (HR, 2.97; 95% CI, 1.09–8.09). The cumulative probabilities for surgery 1 year after diagnosis were 9.1% for patients with CD and 0.9% for patients with UC. Patients with CD and penetrating disease had a 7-fold increase for risk of surgery, compared to patients with inflammatory disease (HR, 7.67; 95% CI, 3.93–14.96). Overall mortality for patients with IBD was 0.7%. Conclusion: In a prospective population-based study, we found that the early course of disease in patients with IBD in Asia was comparable to that of the West. Patients with CD frequently progress to complicated disease and have accelerated use of immunosuppressants. Few patients with early-stage UC undergo surgery in Asia. Increasing our understanding of IBD progression in different populations can help optimize therapy and improve outcomes.
Description: Indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/10245
ISSN: 0016-5085 (Print)
1528-0012 (Electronic)
0016-5085 (Linking)
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