Please use this identifier to cite or link to this item:
Title: Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Authors: Kato, N.
Loh, M.
Takeuchi, F.
Verweij, N.
Wang, X.
Zhang, W.
Kelly, T.N.
Saleheen, D.
Lehne, B.
Leach, I.M.
Drong, A.W.
Abbott, J.
Wahl, S.
Tan, S.T.
Scott, W.R.
Campanella, G.
Chadeau-Hyam, M.
Afzal, U.
Ahluwalia, T.S.
Bonder, M.J.
Chen, P.
Dehghan, A.
Edwards, T.L.
Esko, T.
Go, M.J.
Harris, S.E.
Hartiala, J.
Kasela, S.
Kasturiratne, A.
Khor, C.C.
Kleber, M.E.
Li, H.
Mok, Z.Y.
Nakatochi, M.
Sapari, N.S.
Saxena, R.
Stewart, A.F.
Stolk, L.
Tabara, Y.
Teh, A.L.
Wu, Y.
Wu, J.Y.
Zhang, Y.
Aits, I.
Da Silva Couto Alves, A.
Das, S.
Dorajoo, R.
Hopewell, J.C.
Kim, Y.K.
Koivula, R.W.
Luan, J.
Lyytikäinen, L.P.
Nguyen, Q.N.
Pereira, M.A.
Postmus, I.
Raitakari, O.T.
Bryan, M.S.
Scott, R.A.
Sorice, R.
Tragante, V.
Traglia, M.
White, J.
Yamamoto, K.
Zhang, Y.
Adair, L.S.
Ahmed, A.
Akiyama, K.
Asif, R.
Aung, T.
Barroso, I.
Bjonnes, A.
Braun, T.R.
Cai, H.
Chang, L.C.
Chen, C.H.
Cheng, C.Y.
Chong, Y.S.
Collins, R.
Courtney, R.
Davies, G.
Delgado, G.
Do, L.D.
Doevendans, P.A.
Gansevoort, R.T.
Gao, Y.T.
Grammer, T.B.
Grarup, N.
Grewal, J.
Gu, D.
Wander, G.S.
Hartikainen, A.L.
Hazen, S.L.
He, J.
Heng, C.K.
Hixson, J.E.
Hofman, A.
Hsu, C.
Huang, W.
Husemoen, L.L.
Hwang, J.Y.
Ichihara, S.
Igase, M.
Isono, M.
Justesen, J.M.
Katsuya, T.
Kibriya, M.G.
Kim, Y.J.
Kishimoto, M.
Koh, W.P.
Kohara, K.
Kumari, M.
Kwek, K.
Lee, N.R.
Lee, J.
Liao, J.
Lieb, W.
Liewald, D.C.
Matsubara, T.
Matsushita, Y.
Meitinger, T.
Mihailov, E.
Milani, L.
Mills, R.
Mononen, N.
Müller-Nurasyid, M.
Nabika, T.
Nakashima, E.
Ng, H.K.
Nikus, K.
Nutile, T.
Ohkubo, T.
Ohnaka, K.
Parish, S.
Paternoster, L.
Peng, H.
Peters, A.
Pham, S.T.
Pinidiyapathirage, M.J.
Rahman, M.
Rakugi, H.
Rolandsson, O.
Rozario, M.A.
Ruggiero, D.
Sala, C.F.
Sarju, R.
Shimokawa, K.
Snieder, H.
Sparso, T.
Spiering, W.
Starr, J.M.
Stott, D.J.
Stram, D.O.
Sugiyama, T.
Szymczak, S.
Tang, W.H.
Tong, L.
Trompet, S.
Turjanmaa, V.
Ueshima, H.
Uitterlinden, A.G.
Umemura, S.
Vaarasmaki, M.
van Dam, R.M.
van Gilst, W.H.
van Veldhuisen, D.J.
Viikari, J.S.
Waldenberger, M.
Wang, Y.
Wang, A.
Wilson, R.
Wong, T.Y.
Xiang, Y.B.
Yamaguchi, S.
Ye, X.
Young, R.D.
Young, T.L.
Yuan, J.M.
Zhou, X.
Asselbergs, F.W.
Ciullo, M.
Clarke, R.
Deloukas, P.
Franke, A.
Franks, P.W.
Franks, S.
Friedlander, Y.
Gross, M.D.
Guo, Z.
Hansen, T.
Jarvelin, M.R.
Jorgensen, T.
Jukema, J.W.
Kähönen, M.
Kajio, H.
Kivimaki, M.
Lee, J.Y.
Lehtimäki, T.
Linneberg, A.
Miki, T.
Pedersen, O.
Samani, N.J.
Sorensen, T.I.
Takayanagi, R.
Toniolo, D.
LifeLines Cohort Study
InterAct Consortium
Ahsan, H.
Allayee, H.
Chen, Y.T.
Danesh, J.
Deary, I.J.
Franco, O.H.
Franke, L.
Heijman, B.T.
Holbrook, J.D.
Isaacs, A.
Kim, B.J.
Lin, X.
Liu, J.
März, W.
Metspalu, A.
Mohlke, K.L.
Sanghera, D.K.
Shu, X.O.
van Meurs, J.B.
Vithana, E.
Wickremasinghe, A.R.
Wijmenga, C.
Wolffenbuttel, B.H.
Yokota, M.
Zheng, W.
Zhu, D.
Vineis, P.
Kyrtopoulos, S.A.
Kleinjans, J.C.
McCarthy, M.I.
Soong, R.
Gieger, C.
Scott, J.
Teo, Y.Y.
He, J.
Elliott, P.
Tai, E.S.
van der Harst, P.
Kooner, J.S.
Chambers, J.C.
Keywords: genetic loci influencing blood pressure
Issue Date: 2015
Publisher: Nature Publishing Company
Citation: Nature Genetics.2015;47:1282 - 1293
Abstract: We carried out a trans-ancestry genome-wide association and replication study of blood pressurephenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNAmethylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNAmethylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
Description: Indexed in MEDLINE, SCI, SCI Expanded, BIOSIS Previews
ISSN: 1061-4036 (Print)
1546-1718 (Electronic)
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.