Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo
| dc.contributor.author | Sunil-Chandra, N.P. | |
| dc.contributor.author | Efstathiou, S. | |
| dc.contributor.author | Nash, A.A. | |
| dc.date.accessioned | 2017-08-21T04:06:22Z | |
| dc.date.available | 2017-08-21T04:06:22Z | |
| dc.date.issued | 1992 | |
| dc.description | Indexed in MEDLINE | |
| dc.description.abstract | Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cellenriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein-Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup. | en_US |
| dc.identifier.citation | Journal of General Virology. 1992; 73(12): 3275-3279. | en_US |
| dc.identifier.issn | 0022-1317 (Print) | |
| dc.identifier.issn | 1465-2099 (Electronic) | |
| dc.identifier.issn | 0022-1317 (Linking) | |
| dc.identifier.uri | ||
| dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/17180 | en |
| dc.language.iso | en | en_US |
| dc.publisher | Microbiology Society | en_US |
| dc.subject | B-Lymphocytes-microbiology | en_US |
| dc.subject | Herpesviridae-growth & development | en_US |
| dc.subject | Herpesviridae-pathogenicity | en_US |
| dc.subject.mesh | Gammaherpesvirinae | |
| dc.subject.mesh | Gammaherpesvirinae-genetics | |
| dc.title | Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo | en_US |
| dc.type | Article | en_US |