Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

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dc.contributor.authorWatkins, H.
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dc.contributor.authorWickremasinghe, A.R.
dc.contributor.authorWu, T.
dc.contributor.authorZeggini, E.
dc.contributor.authorZheng, W.
dc.contributor.authorBouchard, C.
dc.contributor.authorEvans, M. K.
dc.contributor.authorGudnason, V.
dc.contributor.authorKardia, S. L. R.
dc.contributor.authorLiu, Y.
dc.contributor.authorPsaty, B. M.
dc.contributor.authorRidker, P. M.
dc.contributor.authorvan Dam, R. M.
dc.contributor.authorMook-Kanamori, D. O.
dc.contributor.authorFornage, M.
dc.contributor.authorProvince, M. A.
dc.contributor.authorKelly, T. N.
dc.contributor.authorFox, E. R.
dc.contributor.authorHayward, C.
dc.contributor.authorvan Duijn, C. M.
dc.contributor.authorTai, E. S.
dc.contributor.authorWong, T. Y.
dc.contributor.authorLoos, R. J. F.
dc.contributor.authorFranceschini, N.
dc.contributor.authorRotter, J. I.
dc.contributor.authorZhu, X.
dc.contributor.authorBierut, L. J.
dc.contributor.authorGauderman, W. J.
dc.contributor.authorRice, K.
dc.contributor.authorMunroe, P. B.
dc.contributor.authorMorrison, A. C.
dc.contributor.authorRao, D. C.
dc.contributor.authorCupples, L. A.
dc.contributor.authorRotimi, C. N.
dc.date.accessioned2019-06-03T09:19:26Z
dc.date.available2019-06-03T09:19:26Z
dc.date.issued2019
dc.descriptionindexed in MEDLINEen_US
dc.description.abstractThe concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.en_US
dc.identifier.citationNature Genetics.2019;51(4):636-648en_US
dc.identifier.issn1061-4036 (Print)
dc.identifier.issn1546-1718 (Electronic)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/20296
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectSmokingen_US
dc.titleMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.en_US
dc.typeArticleen_US

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