Hyperhomocysteinaemia and stroke: a case-control study

dc.contributor.authorRanawaka, U.K.
dc.contributor.authorNiriella, M.A.
dc.contributor.authorHewamadduma, C.A.A.
dc.contributor.authorKanakkahewa, N.
dc.contributor.authorThilakarathna, N.T.
dc.contributor.authorWickremasinghe, A.R.
dc.contributor.authorWijesekera, J.C.
dc.date.accessioned2016-03-24T04:57:15Z
dc.date.available2016-03-24T04:57:15Z
dc.date.issued2004
dc.descriptionOral Presentation Abstract (OP 12), 117th Anniversary Academic Sessions, Sri Lanka Medical Association, 22nd-28th March 2004, The Colombo Plaza and Lionel Memorial Auditorium, Sri Lankaen_US
dc.description.abstractOBJECTIVES: We sought to identify the importance of hyperhomocysteinaemia as an independent risk factor for stroke. METHODOLOGY: This was a case control study of patients with stroke (n=48) and pair matched controls (age and sex matched; n=48) at the Institute of Neurology, NHSL. Prior ethical approval was obtained from the Ethical Review Committee of the SLMA. Fasting total plasma homocysteine (tHcy) was compared between the two groups. Logistic regression analysis was performed to determine the contribution of hyperhomocysteinaemia as a risk factor for stroke, after controlling for other risk factors, using the 50th percentile of tHcy among controls (tHcy 50) as cut-off value. All strokes (n=48) and ischaemic strokes (n=43) were analysed separately. RESULTS: Cases (mean age = 55.69 years) and controls (mean age = 54.64 years) were well matched. tHcy among controls (mean=16.5l umol/1) was higher than observed from elsewhere, even after excluding those with vascular risk factors (mean=13.8 umol/1). The mean tHcy levels were significantly higher in cases (23.12 umol/1) than in controls (16.51 umol/1, p<0.001). There was no significant difference in tHcy between ischaemic and haemorrhagic strokes, and lacunar and non-lacunar strokes. Logistic regression analysis showed that tHcy 50 was an independent risk factor for haemorrhagic strokes (OR 2.583, p=0.05), and for ischaemic strokes (OR 2.663, p=0.05). CONCLUSION: tHcy levels may be higher than usual among Sri Lankan populations. Hyperhocysteinaemia is an independent risk factor for stroke.en_US
dc.identifier.citationSri Lanka Medical Association, 117th Anniversary Academic Sessions. 2004; 36en_US
dc.identifier.issn0009-0895
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/12327
dc.language.isoen_USen_US
dc.publisherSri Lanka Medical Assosiationen_US
dc.subjectHyperhomocysteinemiaen_US
dc.subject.meshStrokeen
dc.subject.meshCase-Control Studiesen
dc.titleHyperhomocysteinaemia and stroke: a case-control studyen_US
dc.typeConference Abstracten_US

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