Effect of antimicrobial agents on inflammatory cytokines in acute Leptospirosis

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dc.contributor.authorFernando, N.
dc.contributor.authorde Silva, R.
dc.contributor.authorHadunnetti, S.M.
dc.contributor.authorKarunanayake, L.
dc.contributor.authorde Silva, N.L.
dc.contributor.authorde Silva, H.J.
dc.contributor.authorRajapakse, S.
dc.contributor.authorPremawansa, S.
dc.date.accessioned2018-07-05T03:50:39Z
dc.date.available2018-07-05T03:50:39Z
dc.date.issued2018
dc.descriptionIndexed In MEDLINEen_US
dc.description.abstractThe aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (P = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses (P < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = -0.315; P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy.2018;62(5):e02312-17en_US
dc.identifier.issn0066-4804 (Print)
dc.identifier.issn1098-6596 (Electronic)
dc.identifier.issn0066-4804 (Linking)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/18919
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.subjectLeptospirosisen_US
dc.subjectLeptospirosis-Drug therapyen
dc.subjectAnti-Infective Agents
dc.subjectAnti-Infective Agents-therapeutic useen
dc.subjectCytokines-blooden
dc.titleEffect of antimicrobial agents on inflammatory cytokines in acute Leptospirosisen_US
dc.typeArticleen_US

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