Treatment of lamivudine-resistant hepatitis B infection in post-renal transplant patients with Adefovir dipivoxil: preliminary results

No Thumbnail Available

Date

2006

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

We report the treatment outcome in six post-renal transplant patients with lamivudine-resistant hepatitis B virus (LR-HBV) infection using adefovir dipivoxil and followed for 6 to 18 months. Posttransplant immunosuppressive therapy was not altered. Adefovir dipivoxil effectively suppressed hepatitis B virus DNA and improved alanine transferase, although DNA suppression seemed dependent on continued therapy. Nephrotoxicity led to withdrawal of the drug in three patients. This may limit therapeutic usefulness in a significant proportion of post-renal transplant patients with LR-HBV infection.

Description

Indexed in MEDLINE

Keywords

Citation

Transplantation Proceedings. 2006; 38(9): 3118-120

Endorsement

Review

Supplemented By

Referenced By