Ethanolic Extract of Terminalia catappa Kernel: A Natural Remedy with Promising Pharmacological Potential.

Abstract

A relationship between humans and nature began with our ancestral reliance on natural resources for survival and health. This relationship has profoundly influenced the field of pharmacology through the discovery and utilization of natural product drugs, demonstrating the enduring importance of nature in medicine and the ongoing exploration of its therapeutic potential. This study investigates the pharmacological potential of the ethanolic extract of Ceylon almond kernel (Terminalia catappa), highlighting its antioxidant (IC50 = 21.68 ± 1.97 µg/mL), anti-inflammatory (IC50 = 180.14 ± 3.99 µg/mL) and α-amylase inhibitory (IC50 = 147.77 ± 4.74 µg/mL) activities. It also showed antibacterial activity against various pathogens and minimal UV protection (SPF = 5.27 ± 0.63). These results suggest that the Ceylon almond kernel could be a promising natural source for pharmaceutical applications and drug development.