Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract

dc.contributor.authorAmarakoon, A.M.en_US
dc.contributor.authorTappia, P.S.en_US
dc.contributor.authorGrimble, R.F.en_US
dc.date.accessioned2014-11-19T04:40:14Z
dc.date.available2014-11-19T04:40:14Z
dc.date.issued1995
dc.description.abstractStudies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. In the vitamin E sufficient group a significantly lower IL-6 concentration than in vitamin E deficient animals was observed. Addition of tea extract to the diet produced a similar reduction in IL-6, but no synergism occurred in the presence of both vitamin E and tea extract. However, a significantly lower caeruloplasmin and a significantly higher liver glutathione concentration was observed in rats fed both substances. It is suggested that consideration of dietary components which alter antioxidant/oxidant status may contribute towards treatment of inflammatory/autoimmune diseases.en_US
dc.identifier.departmentChemistryen_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/3788
dc.publisherinflamm researchen_US
dc.titleEndotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract
dc.typearticleen_US

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