The Effect of acyclovir on the acute and latent murine gammaherpesvirus-68 infection of mice

dc.contributor.authorSunil-Chandra, N.P.
dc.contributor.authorEfstathiou, S.
dc.contributor.authorNash, A.A.
dc.date.accessioned2017-09-14T14:27:50Z
dc.date.available2017-09-14T14:27:50Z
dc.date.issued1994
dc.description.abstractMice inoculated intranasally with murine gammaherpesvirus-68 were used to evaluate the efficacy of acyclovir (ACV) in the treatment of acute and latent infections. Effectiveness was measured by infectious virus assay of the lung (site of active replication) and infectious centre assay of spleen cells (site of latency). Intraperitoneal administration of ACV at 6-h intervals starting soon after inoculation was more effective in reducing infectious virus in the lung than was treatment with 12-hourly injections commencing 3 days post-infection.en_US
dc.identifier.citationAntiviral Chemistry and Chemotherapy. 1994; 5(6): 290-296en_US
dc.identifier.issn0956-3202 (Print)
dc.identifier.issn2040-2066 (Electronic)
dc.identifier.issn0956-3202 (Linking)
dc.identifier.other10.1177/095632029400500502en
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/17469
dc.language.isoen_USen_US
dc.publisherSage Publishingen_US
dc.relation.urihttp://journals.sagepub.com/doi/abs/10.1177/095632029400500502en
dc.subject.meshGammaherpesvirinae
dc.subject.meshGammaherpesvirinae-pathogenicity
dc.subject.meshGammaherpesvirinae-physiology
dc.subject.meshGammaherpesvirinae-drug effects
dc.subject.meshHerpesviridae Infections-virology
dc.subject.meshHerpesviridae Infections
dc.subject.meshHerpesviridae-drug effects
dc.subject.meshHerpesviridae-pathogenicity
dc.subject.meshVirus Latency
dc.titleThe Effect of acyclovir on the acute and latent murine gammaherpesvirus-68 infection of miceen_US
dc.typeArticleen_US

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