Two new antioxidant active polyketides from Penicillium citrinum, an endolichenic fungus isolated from Parmotrema species in Sri Lanka

Samanthi, K.A.U.; Wickramaarachchi, S.; Wijeratne, E.M.K.; Paranagama, P.A.

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dc.contributor.author	Samanthi, K.A.U.
dc.contributor.author	Wickramaarachchi, S.
dc.contributor.author	Wijeratne, E.M.K.
dc.contributor.author	Paranagama, P.A.
dc.date.accessioned	2015-07-03T06:25:24Z
dc.date.available	2015-07-03T06:25:24Z
dc.date.issued	2015
dc.identifier.citation	Samanthi, K.A.U., Wickramaarachchi, S., Wijeratne, E.M.K. and Paranagama, P.A., 2015. Two new antioxidant active polyketides from Penicillium citrinum, an endolichenic fungus isolated from Parmotrema species in Sri Lanka, Journal of the National Science Foundation of Sri Lanka, 43 (2): 119-126.	en_US
dc.identifier.uri
dc.identifier.uri	http://repository.kln.ac.lk/handle/123456789/8667
dc.description.abstract	Bioassay guided fractionation of the ethyl acetate extract of a laboratory culture of Penicillium citrinum, an endolichenic fungal strain isolated from a Parmotrema species in Sri Lanka, led to the isolation of two new fungal polyketides (1 and 2). The structures of these compounds were determined on the basis of their 1D NMR, 2D NMR and FABMS spectroscopic data. The two compounds (1 and 2) showed radical scavenging activity with IC50 values of 159.7 ± 22.3 μg/mL and 68.6 ± 4.3 μg/mL, respectively in DPPH antioxidant assay. The antioxidant activity of compound 2 was comparable to the standard antioxidant compound butylated hydroxytoluene (BHT).	en_US
dc.language.iso	en	en_US
dc.publisher	National Science Foundation of Sri Lanka	en_US
dc.subject	Antioxidant activity, biosynthesis, endolichenic fungus, Penicillium citrinum, polyketides, secondary metabolites.	en_US
dc.title	Two new antioxidant active polyketides from Penicillium citrinum, an endolichenic fungus isolated from Parmotrema species in Sri Lanka	en_US
dc.type	Article	en_US