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Validation of a Gastro-oesophageal Reflux Disease (GERD) Specific Screening Instrument for Epidemiological Purposes

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dc.contributor.author Amarasiri, W.A.D.L.
dc.contributor.author Pathmeswaran, A.
dc.contributor.author Ranasinha, C.
dc.contributor.author de Silva, H.J.
dc.date.accessioned 2015-05-15T04:23:55Z
dc.date.available 2015-05-15T04:23:55Z
dc.date.issued 2007
dc.identifier.citation Amarasiri, W.A.D.L., Pathmeswaran, A., Ranasinha, C. and de Silva, H.J., 2007. Validation of a Gastro-oesophageal Reflux Disease (GERD) Specific Screening Instrument for Epidemiological Purposes, Proceedings of the Annual Research Symposium 2007, Faculty of Graduate Studies, University of Kelaniya, pp 145. en_US
dc.identifier.uri
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/7456
dc.description.abstract Introduction: The prevalence of GERD is increasing worldwide: the community prevalence in Sri Lanka is not known. Objectives : To develop a practical clinical score to screen for GERD in the community and assess whether a score using both symptom frequency and severity correlates better to an objective measure of GERD than one using only symptom frequency. Methodology : 100 patients (endoscopy positive - which included patients with all grades of oesophagitis) and 150 controls (comparable in age and gender) faced a GERDspecific interviewer-administered questionnaire assessing seven upper gastro-intestinal symptoms. Each symptom was graded using Likert scales for frequency (4-items) and severity (5-items) and two scores were generated. Score 1 being the sum of frequency of symptoms while score 2 was the sum of products of frequency and severity of each. All patients then underwent 24-h ambulatory pHmetry. Both symptom scores were compared against 24-h pHmetry parameters as it is considered the gold standard to diagnose GERD. Cut-off values were determined by receiver-operating characteristic curves. Results : For both scores, mean scores of cases were significantly higher than controls (p=O.OOO). The cut-off score for score 1 was 2': 10.50 (sensitivity 92.0 %; specificity 78.7 %; area under the curve- 0.937). The cut-off score for score 2 was 2': 12.50 (sensitivity 90.0%; specificity 78.0%; area under the curve - 0.929). Both showed high reproducibility (Intra class correlation coefficient score1: 0.94 and score2: 0.82). There was good correlation between both symptom scores and 24-h pHmetry parameters (Spearman rank correlation, p=0.01), but score 2 showed a significantly better correlation. Conclusion: Our GERD questionnaire is valid, reproducible and showed better correlation with an objective test when both severity and frequency of symptoms were scored than frequency alone. en_US
dc.language.iso en en_US
dc.publisher University of Kelaniya en_US
dc.title Validation of a Gastro-oesophageal Reflux Disease (GERD) Specific Screening Instrument for Epidemiological Purposes en_US
dc.type Article en_US


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