Digital Repository

Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka

Show simple item record

dc.contributor.author Jayasumana, C.
dc.contributor.author Paranagama, P.A.
dc.contributor.author Agampodi, S.
dc.contributor.author Wijewardane, C.
dc.contributor.author Gunatilake, S.
dc.contributor.author Siribaddana, S
dc.date.accessioned 2015-01-28T08:21:57Z
dc.date.available 2015-01-28T08:21:57Z
dc.date.issued 2015
dc.identifier Chemistry en_US
dc.identifier.citation Jayasumana Channa, Paranagama Priyani, Agampodi Suneth, Wijewardane Chinthaka, Gunatilake Sarath, Siribaddana Sisira (2015) Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka, Environmental Health, 14(6), doi:10.1186/1476-069X-14-6. en_US
dc.identifier.uri
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/5204
dc.description.abstract Background The chronic kidney disease of unknown etiology (CKDu) among paddy farmers in was first reported in 1994 and has now become most important public health issue in dry zone of Sri Lanka. The objective was to identify risk factors associated with the epidemic in an area with high prevalence. Methods A case control study was carried out in Padavi-Sripura hospital in Trincomalee district. CKDu patients were defined using health ministry criteria. All confirmed cases (N = 125) fulfilling the entry criteria were recruited to the study. Control selection (N = 180) was done from people visiting the hospital for CKDu screening. Socio-demographic and data related to usage of applying pesticides and fertilizers were studied. Drinking water was also analyzed using ICP-MS and ELISA to determine the levels of metals and glyphosate. Results Majority of patients were farmers (N = 107, 85.6%) and were educated up to ‘Ordinary Level’ (N = 92, 73.6%). We specifically analyzed for the effect modification of, farming by sex, which showed a significantly higher risk for male farmers with OR 4.69 (95% CI 1.06- 20.69) in comparison to their female counterparts. In the multivariable analysis the highest risk for CKDu was observed among participants who drank well water (OR 2.52, 95% CI 1.12-5.70) and had history of drinking water from an abandoned well (OR 5.43, 95% CI 2.88- 10.26) and spray glyphosate (OR 5.12, 95% CI 2.33-11.26) as a pesticide. Water analysis showed significantly higher amount of hardness, electrical conductivity and glyphosate levels in abandoned wells. In addition Ca, Mg, Ba, Sr, Fe, Ti, V and Sr were high in abandoned wells. Surface water from reservoirs in the endemic area also showed contamination with glyphosate but at a much lower level. Glyphosate was not seen in water samples in the Colombo district. Conclusion The current study strongly favors the hypothesis that CKDu epidemic among farmers in dry zone of Sri Lanka is associated with, history of drinking water from a well that was abandoned. In addition, it is associated with spraying glyphosate and other pesticides in paddy fields. Farmers do not use personnel protective equipments and wears scanty clothing due to heat when spraying pesticides. en_US
dc.language.iso en en_US
dc.publisher Environmental Health Journal en_US
dc.subject Chronic Kidney disease en_US
dc.subject Tubulointerstitial nephritis en_US
dc.subject Well water en_US
dc.subject Herbicides en_US
dc.subject Glyphosate en_US
dc.subject Sri Lanka en_US
dc.title Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account