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The antimalarial activity of Ru?chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces

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dc.contributor.author Martínez, A. en_US
dc.contributor.author Rajapakse, C.S.K. en_US
dc.contributor.author Jalloh, D. en_US
dc.contributor.author Dautriche, C. en_US
dc.contributor.author Sánchez-Delgado, R.A. en_US
dc.date.accessioned 2014-11-19T04:41:02Z
dc.date.available 2014-11-19T04:41:02Z
dc.date.issued 2009
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/3880
dc.description.abstract We have measured water/n-octanol partition coefficients, pK a values, heme binding constants, and heme aggregation inhibition activity of a series of ruthenium??-arene?chloroquine (CQ) complexes recently reported to be active against CQ-resistant strains of Plasmodium falciparum. Measurements of heme aggregation inhibition activity of the metal complexes near water/n-octanol interfaces qualitatively predict their superior antiplasmodial action against resistant parasites, in relation to CQ; we conclude that this modified method may be a better predictor of antimalarial potency than standard tests in aqueous acidic buffer. Some interesting tendencies emerge from our data, indicating that the antiplasmodial activity is related to a balance of effects associated with the lipophilicity, basicity, and structural details of the compounds studied. en_US
dc.publisher Journal of Biological Inorganic Chemistry en_US
dc.subject Chloroquine en_US
dc.subject Ruthenium en_US
dc.subject Malaria en_US
dc.subject Heme aggregation en_US
dc.subject Lipophilicity en_US
dc.title The antimalarial activity of Ru?chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces
dc.type article en_US
dc.identifier.department Inorganic Biochemistry en_US


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