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Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract

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dc.contributor.author Amarakoon, A.M. en_US
dc.contributor.author Tappia, P.S. en_US
dc.contributor.author Grimble, R.F. en_US
dc.date.accessioned 2014-11-19T04:40:14Z
dc.date.available 2014-11-19T04:40:14Z
dc.date.issued 1995
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/3788
dc.description.abstract Studies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. In the vitamin E sufficient group a significantly lower IL-6 concentration than in vitamin E deficient animals was observed. Addition of tea extract to the diet produced a similar reduction in IL-6, but no synergism occurred in the presence of both vitamin E and tea extract. However, a significantly lower caeruloplasmin and a significantly higher liver glutathione concentration was observed in rats fed both substances. It is suggested that consideration of dietary components which alter antioxidant/oxidant status may contribute towards treatment of inflammatory/autoimmune diseases. en_US
dc.publisher inflamm research en_US
dc.title Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract
dc.type article en_US
dc.identifier.department Chemistry en_US


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