Browsing Chemistry by Author "Udukala, Dinusha N."

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Design, synthesis and evaluation of 3-hydroxy quinazolinone derivatives as urease inhibitors against Helicobacter pylori

Ruhunage, S. A.; Udukala, Dinusha N.; Gunaratna, Medha J. (Institute of Chemistry Ceylon, 2020)

Gastritis is a common virulent disease found in the present world. The main pathogen which can cause gastritis is Helicobacter pylori and the infection from this bacterium in the upper gastrointestinal tract can lead to ...
Design, synthesis, and evaluation of 2, 3-disubstituted quinazolin-4(3H)-one derivatives as urease inhibitors against Helicobacter pylori

Madujith, E. A. D. N.; Gunaratna, Medha J.; Udukala, Dinusha N. (Institute of Chemistry Ceylon, 2020)

Helicobacter pylori is a pathogenic bacterium that causes ulcers and inflammations in the stomach lining. This bacterium produces urease enzyme which catalyzes the hydrolysis of urea in the stomach to carbon dioxide gas ...
Evaluation of urease inhibitory activity in the testa (seed coat) and the mesocarp of Cocos nucifera variety Aurantiaca

Ranasinghe, Y. E.; Udukala, Dinusha N.; Gunaratna, Medha. J. (2020)

Helicobacter pylori is an organism in the gastric mucosa of humans, which releases the enzyme urease facilitating its colonization, leading to gastritis and gastric cancer. The existing pharmacological agents against ...
Synthesis, evaluation and structure activity relationship study of 2-phenyl-3H-quinazolinone derivatives as urease inhibitors against Helicobacter pylori

Alwis, Y. Vindula; Gunaratna, Medha J.; Udukala, Dinusha N. (Institute of Chemistry Ceylon, 2020)

Urease is a nickel containing metalloenzyme, which catalyzes the hydrolysis of urea into ammonia and carbon dioxide. It is an essential enzyme for Helicobacter pylori, which is a bacterium that has an ability to colonize ...
Urease inhibitory activity of the leaves and fruits of Trichosanthes cucumerina Linn.

Dharmajeewa, H. D. O. P.; Gunaratna, Medha J.; Udukala, Dinusha N. (Institute of Chemistry Ceylon, 2020)

Helicobacter pylori is a bacterium found in stomach which secretes bacterial urease, a major virulent factor to cause peptic ulcers. Hence, numerous studies have been carried out to investigate urease inhibitory activity ...

Browsing Chemistry by Author "Udukala, Dinusha N."

Browsing Chemistry by Author "Udukala, Dinusha N."

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