The cyclic enediynes, a relatively new class of antitumor antibiotics are strong DNA cleavage agents and exhibit remarkable antitumor activities both in vitro and in vivo. Naturally occurring enediyne antitumor antibiotics ...

Irradiation of the nine-membered ring enediyne precursor, which has one of its triple bonds masked as cyclopropenone, efficiently (? = 0.34) generates the reactive 4,5-benzocyclonona-2,6-diynol. The latter rapidly equilibrates ...

The extreme cytotoxicity of natural enediyne antibiotics is attributed to the ability of the (Z)-3-ene-1,5-diyne fragment incorporated into a 10- or 9-membered ring cyclic system to undergo Bergman cyclization and producing ...