Pandithavidana D R; Popik V V
(The Southeast Regional Meeting of the American Chemical Society (SERMACS), Nashville, TN, USA, 2008)
The extreme cytotoxicity of natural enediyne antibiotics is attributed to the ability of the (Z)-3-ene-1,5-diyne fragment incorporated into a 10- or 9-membered ring cyclic system to undergo Bergman cyclization and producing ...