Digital Repository

Evaluation of phytochemical composition and novel bioactivities from fresh fruit of Garcinia quaesita Pierre

Show simple item record

dc.contributor.author Ekanayaka, K.S.J.
dc.contributor.author Gunaratna, Medha J.
dc.date.accessioned 2024-08-15T04:24:33Z
dc.date.available 2024-08-15T04:24:33Z
dc.date.issued 2024
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/27979
dc.description.abstract The fruit rind of Garcinia quaesita Pierre is known as a condiment with therapeutic potential, including antioxidant, antihyperglycemic, and anti-proliferative effects. However, there has been a lack of in-depth investigation into its phytochemical composition and its activities related to anti-inflammatory, and anti-tyrosinase activities. In this study a 1:1 ethanol : water extract of fresh fruit of Garcinia quaesita was used. Preliminary phytochemical screening revealed the presence of numerous bioactive compounds, including alkaloids, polyphenols, flavonoids, glycosides, coumarins, anthraquinones, steroids, terpenoids, saponin, and xanthoproteins. The Total Phenolic Content (TPC) of the fruit extract of G. quaesita was 3053.25 ± 30.07 μg GAE g−1, and Total Flavonoid Content (TFC) was 443.19 ± 4.76 μg CE g−1. The extract exhibited moderate antioxidant activity (IC50 238.14 ± 0.68 μg mL−1) compared to ascorbic acid. In anti-inflammatory assays, compared to O-acetyl salicylic acid, the extract showed notably higher inhibitory effects against egg albumin denaturation and heat-induced hemolysis with lower IC50 values of 762.49 ± 1.70 μg mL−1 and 617.66 ± 1.75 ìg mL−1 respectively. Correlation analysis highlighted strong positive correlations between TPC and antioxidant (r=0.801) and anti-inflammatory (r=0.725 and r=0.605) activities, highlighting the role of TPC. At 4 mg mL−1, the fruit extract of Garcinia quaesita Pierre exhibited lower inhibitory activity of tyrosinase with an IC50 value of 3.31 ± 0.04 mg mL−1, than kojic acid. Additionally, the SPF value at 2 mg mL−1 was 15, indicating moderate UV protection. In conclusion, this study suggests the potential use of fresh G. quaesita fruit extract for functional foods and cosmetics, owing to its rich phytochemical composition and bioactivities, especially in antioxidative and anti-inflammatory domains. en_US
dc.publisher Indian Journal.com en_US
dc.title Evaluation of phytochemical composition and novel bioactivities from fresh fruit of Garcinia quaesita Pierre en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account