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Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds

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dc.contributor.author Shevkar, C.
dc.contributor.author Pradhan, P.
dc.contributor.author Armarkar, A.
dc.contributor.author Pandey, K.
dc.contributor.author Kalia, K.
dc.contributor.author Paranagama, P.
dc.contributor.author Kate, A. S.
dc.date.accessioned 2022-10-31T08:40:33Z
dc.date.available 2022-10-31T08:40:33Z
dc.date.issued 2022
dc.identifier.citation Shevkar, C., Pradhan, P., Armarkar, A., Pandey, K., Kalia, K., Paranagama, P., & Kate, A. S. (2022). Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds. Chemistry & Biodiversity, 19(4). https://doi.org/10.1002/cbdv.202100976 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/25403
dc.description.abstract Fungi are known to produce diverse scaffolds possessing unique biological activities, however, to date, no molecule discovered from a fungal source has reached the market as an anti-cancer drug. Every year number of cytotoxic molecules of fungal origin are getting published and critical analysis of those compounds is necessary to identify the potent ones. A review mentioning the best cytotoxic fungal metabolites and their status in the drug development was published in 2014. In this report, we have included 176 cytotoxic molecules isolated from fungi after 2014 and categorized them according to their potencies such as IC50 values below 1 μM, 1–5 μM, and 5–10 μM. The emphasis was given to those 42 molecules which have shown IC50 less than 1 μM and discussed to a great extent. This review shall provide potent scaffolds of fungal origin which can be given priority in the development as a drug candidate for cancer therapeutics. en_US
dc.publisher Chemistry & Biodiversity en_US
dc.subject potent fungal metabolites, cancer drug discovery, endolichenic fungi, endophytic fungi, terrestrial and marine fungi. en_US
dc.title Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds en_US


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