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Identification of Novel Bioactive Compounds, Neurosporalol 1 and 2 from anEndolichenic Fungus, Neurospora ugadawe Inhabited in the Lichen Host,Graphis tsunodae Zahlbr. from Mangrove Ecosystem in Puttalam Lagoon, Sri Lanka

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dc.contributor.author Maduranga, H.
dc.contributor.author Weerasinghe, W.
dc.contributor.author Attanayake, R.
dc.contributor.author Santhirasegaram, S.
dc.contributor.author Shevkar, C.
dc.contributor.author Kate, A.S.
dc.contributor.author Weerakoon, G.
dc.contributor.author Samanthi, K.
dc.contributor.author Kalia, K.
dc.contributor.author Paranagama, P. A.
dc.date.accessioned 2021-11-01T19:43:06Z
dc.date.available 2021-11-01T19:43:06Z
dc.date.issued 2021
dc.identifier.citation Maduranga, H., Weerasinghe, W., Attanayake, R., Santhirasegaram, S., Shevkar, C., Kate, A., Weerakoon, G., Samanthi, K., Kalia, K., & Paranagama, P. A. (2021b). Identification of Novel Bioactive Compounds, Neurosporalol 1 and 2 from anEndolichenic Fungus, Neurospora ugadawe Inhabited in the Lichen Host,Graphis tsunodae Zahlbr. from Mangrove Ecosystem in Puttalam Lagoon, Sri Lanka. Asian Journal of Chemistry, 33(6), 1425–1432. https://doi.org/10.14233/ajchem.2021.23229 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/23808
dc.description.abstract Endolichenic fungi (ELF) have been recognized as a promising source of bioactive secondary metabolites. Sri Lanka, a biodiversity hotspot, harbours a remarkable diversity in mangrove ecosystems. In the present study, endolichenic fungi obtained from mangrove lichens of Puttalam lagoon were studied for their secondary metabolites. An endolichenic fungus, Neurospora ugadawe, isolated from the lichen host Graphis tsunodae Zahlbr. was identified up to the species level. Secondary metabolites of N. ugadawe were extracted into ethyl acetate and crude extract showed promising antioxidant and anti-inflammatory activities. Bioassay guided separation on silica gel column chromatography and preparative TLC were performed to isolate the bioactive pure compounds. Two novel bioactive pure compounds were identified as Neurosporalol 1 and Neurosporalol 2. Neurosporalol 1 showed the highest antioxidant activity compared with the positive control BHT. Further, this compound showed very low anti-inflammatory activity compared to that of the positive control aspirin. Neurosporalol 2 showed comparable antioxidant and moderate anti-inflammatory activities. en_US
dc.publisher Asian Journal of Chemistry en_US
dc.subject Endolichenic fungus, Neurospora ugadawe, Neurosporalol 1, Neurosporalol 2, Bioactivities en_US
dc.title Identification of Novel Bioactive Compounds, Neurosporalol 1 and 2 from anEndolichenic Fungus, Neurospora ugadawe Inhabited in the Lichen Host,Graphis tsunodae Zahlbr. from Mangrove Ecosystem in Puttalam Lagoon, Sri Lanka en_US


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