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Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review

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dc.contributor.author Wethalawe, A.N.
dc.contributor.author Alwis, Y.V.
dc.contributor.author Udukala, D.N.
dc.contributor.author Paranagama, P.A.
dc.date.accessioned 2021-10-31T19:59:38Z
dc.date.available 2021-10-31T19:59:38Z
dc.date.issued 2021
dc.identifier.citation Wethalawe, A.N.; Alwis, Y.V.; Udukala, D.N.; Paranagama, P.A. Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review. Molecules 2021, 26, 3901. https://doi.org/ 10.3390/molecules26133901 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/23654
dc.description.abstract A lichen is a symbiotic relationship between a fungus and a photosynthetic organism, which is algae or cyanobacteria. Endolichenic fungi are a group of microfungi that resides asymptomatically within the thalli of lichens. Endolichenic fungi can be recognized as luxuriant metabolic artists that produce propitious bioactive secondary metabolites. More than any other time, there is a worldwide search for new antibiotics due to the alarming increase in microbial resistance against the currently available therapeutics. Even though a few antimicrobial compounds have been isolated from endolichenic fungi, most of them have moderate activities, implying the need for further structural optimizations. Recognizing this timely need and the significance of endolichenic fungi as a promising source of antimicrobial compounds, the activity, sources and the structures of 31 antibacterial compounds, 58 antifungal compounds, two antiviral compounds and one antiplasmodial (antimalarial) compound are summarized in this review. In addition, an overview of the common scaffolds and structural features leading to the corresponding antimicrobial properties is provided as an aid for future studies. The current challenges and major drawbacks of research related to endolichenic fungi and the remedies for them have been suggested. en_US
dc.publisher Molecules 2021 en_US
dc.subject endolichenic fungi; antibacterial; antifungal; antiviral; antiplasmodial; secondarymetabolites en_US
dc.title Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review en_US


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